乙二醇单甲醚和丙二醇单甲醚：代谢、处置及亚慢性吸入毒性研究
Ethylene glycol monomethyl ether and propylene glycol monomethyl ether: metabolism, disposition, and subchronic inhalation toxicity studies.
作者信息
Miller R R, Hermann E A, Young J T, Landry T D, Calhoun L L
出版信息
Environ Health Perspect. 1984 Aug;57:233-9. doi: 10.1289/ehp.8457233.
Abstract
Short-term and subchronic vapor inhalation studies have shown that there are pronounced differences in the toxicological properties of ethylene glycol monomethyl ether (EGME) and propylene glycol monomethyl ether (PGME). Overexposure to EGME has resulted in adverse effects on testes, bone marrow and lymphoid tissues in laboratory animals. PGME does not affect these tissues, and instead, overexposure to PGME has been associated with increases in liver weight and central nervous system depression. EGME is primarily oxidized to methoxyacetic acid in male rats, while PGME apparently undergoes O-demethylation to form propylene glycol. Since methoxyacetic acid has been shown to have the same spectrum of toxicity as EGME in male rats, the observed differences in the toxicological properties of EGME and PGME are thought to be due to the fact that the two materials are biotransformed via different routes to different types of metabolites.
摘要
短期和亚慢性吸入蒸气研究表明，乙二醇单甲醚（EGME）和丙二醇单甲醚（PGME）的毒理学特性存在显著差异。在实验动物中，过量接触EGME已对睾丸、骨髓和淋巴组织产生不良影响。PGME不会影响这些组织，相反，过量接触PGME与肝脏重量增加和中枢神经系统抑制有关。在雄性大鼠中，EGME主要氧化为甲氧基乙酸，而PGME显然发生O-去甲基化形成丙二醇。由于甲氧基乙酸在雄性大鼠中已显示出与EGME相同的毒性谱，因此EGME和PGME毒理学特性的观察到的差异被认为是由于这两种物质通过不同途径生物转化为不同类型的代谢物这一事实。
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本文引用的文献
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