Nagano K, Nakayama E, Oobayashi H, Nishizawa T, Okuda H, Yamazaki K
Environ Health Perspect. 1984 Aug;57:75-84. doi: 10.1289/ehp.845775.
Past studies on the toxicological effects of ethylene glycol alkyl ethers as well as the recent data on these chemicals in Japan are reviewed. Only a few researchers have participated in the study of ethylene glycol alkyl ethers in Japan. The effects of ethylene glycol alkyl ethers on testis and embryotoxic effects of ethylene glycol monomethyl ether (EGM) have been studied, as has the teratogenicity of ethylene glycol dimethyl ether (EGdM). Studies on ethylene glycol alkyl ethers and related compounds administered to mice by oral gavage revealed the occurrence of testicular atrophy and decreased white blood cell count by EGM, EGdM, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate, and the toxicity was related to their chemical structure. On the other hand, ethylene glycol, ethylene glycol monopropyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monoacetate or ethylene glycol diacetate showed no such an effect. Studies on EGM using hamsters or guinea pigs revealed the occurrence of testicular atrophy similar to that observed in mice. In regard to the methyl ethers of other glycols, there is no convincing evidence that propylene glycol monomethyl ether, diethylene glycol monomethyl ether or diethylene glycol dimethyl ether causes testicular atrophy in mice. Teratological studies of EGM and EGdM revealed embryotoxic effects in mice.
本文综述了以往关于乙二醇烷基醚毒理学效应的研究以及日本近期有关这些化学品的数据。在日本，仅有少数研究人员参与了乙二醇烷基醚的研究。已对乙二醇烷基醚对睾丸的影响、乙二醇单甲醚（EGM）的胚胎毒性效应以及乙二醇二甲醚（EGdM）的致畸性进行了研究。对通过灌胃给予小鼠乙二醇烷基醚及相关化合物的研究表明，EGM、EGdM、乙二醇单甲醚乙酸酯、乙二醇单乙醚和乙二醇单乙醚乙酸酯会导致睾丸萎缩和白细胞计数降低，且毒性与其化学结构有关。另一方面，乙二醇、乙二醇单丙醚、乙二醇单丁醚、乙二醇单苯醚、乙二醇单乙酸酯或乙二醇二乙酸酯未显示出此类效应。使用仓鼠或豚鼠对EGM进行的研究表明，会出现与在小鼠中观察到的类似的睾丸萎缩。关于其他二醇的甲醚，没有令人信服的证据表明丙二醇单甲醚、二甘醇单甲醚或二甘醇二甲醚会导致小鼠睾丸萎缩。对EGM和EGdM的致畸学研究表明，它们对小鼠具有胚胎毒性效应。
