抗炎药物对全身炎症略有升高的老年男性餐后和运动后肌肉蛋白质合成无影响。
No effect of anti-inflammatory medication on postprandial and postexercise muscle protein synthesis in elderly men with slightly elevated systemic inflammation.
作者信息
Dideriksen K, Reitelseder S, Malmgaard-Clausen N M, Bechshoeft R, Petersen R K, Mikkelsen U R, Holm L
机构信息
Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
出版信息
Exp Gerontol. 2016 Oct;83:120-9. doi: 10.1016/j.exger.2016.07.016. Epub 2016 Aug 3.
BACKGROUND
Based on circulating C-reactive protein (CRP) levels, some individuals develop slightly increased inflammation as they age. In elderly inflamed rats, the muscle response to protein feeding is impaired, whereas it can be maintained by treatment with non-steroidal anti-inflammatory drugs (NSAIDs). It is unknown whether this applies to elderly humans with increased inflammation. Thus, the muscle response to whey protein bolus ingestion with and without acute resistance exercise was compared between healthy elderly individuals and elderly individuals with slightly increased inflammation±NSAID treatment.
METHODS
Twenty-four elderly men (>60years) were recruited. Of those, 14 displayed a slightly increased systemic inflammation (CRP>2mg/l) and were randomly assigned to NSAID (Ibuprofen 1800mg/day) or placebo treatment for 1week. The remaining 10 elderly individuals served as healthy controls (CRP<1mg/l). The muscle protein synthetic response was measured as the fractional synthetic rate (FSR) and p70S6K phosphorylation-to-total protein ratio.
RESULTS
The basal myofibrillar FSR and the myofibrillar FSR responses to whey protein bolus ingestion with and without acute resistance exercise were maintained in inflamed elderly compared to healthy controls (p>0.05) and so was p70S6K phosphorylation. Moreover, NSAID treatment did not significantly improve the myofibrillar and connective tissue FSR responses or reduce the plasma CRP level in inflamed, elderly individuals (p>0.05).
CONCLUSION
A slight increase in systemic inflammation does not affect the basal myofibrillar FSR or the myofibrillar FSR responses, which suggests that elderly individuals with slightly increased inflammation can benefit from protein ingestion and resistance exercise to stimulate muscle protein anabolism. Moreover, the NSAID treatment did not significantly affect the myofibrillar or connective tissue FSR responses to protein ingestion and acute resistance exercise.
背景
基于循环C反应蛋白（CRP）水平，一些个体随着年龄增长会出现炎症略有增加的情况。在老年炎症大鼠中，肌肉对蛋白质喂养的反应受损，而使用非甾体抗炎药（NSAIDs）治疗可维持该反应。目前尚不清楚这是否适用于炎症增加的老年人群。因此，比较了健康老年个体与炎症略有增加±NSAIDs治疗的老年个体在摄入乳清蛋白推注并进行和不进行急性抗阻运动时的肌肉反应。
方法
招募了24名老年男性（>60岁）。其中，14名表现出全身炎症略有增加（CRP>2mg/l），并被随机分配接受NSAIDs（布洛芬1800mg/天）或安慰剂治疗1周。其余10名老年个体作为健康对照（CRP<1mg/l）。肌肉蛋白质合成反应通过分数合成率（FSR）和p70S6K磷酸化与总蛋白比率来衡量。
结果
与健康对照组相比，炎症老年个体中基础肌原纤维FSR以及摄入乳清蛋白推注并进行和不进行急性抗阻运动时的肌原纤维FSR反应均得以维持（p>0.05），p70S6K磷酸化情况也是如此。此外，NSAIDs治疗并未显著改善炎症老年个体的肌原纤维和结缔组织FSR反应，也未降低其血浆CRP水平（p>0.05）。
结论
全身炎症略有增加并不影响基础肌原纤维FSR或肌原纤维FSR反应，这表明炎症略有增加的老年个体可从蛋白质摄入和抗阻运动中获益，以刺激肌肉蛋白质合成代谢。此外，NSAIDs治疗对蛋白质摄入和急性抗阻运动引起的肌原纤维或结缔组织FSR反应无显著影响。
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