Jantaratnotai Nattinee, Mosikanon Kanokwan, Lee Yena, McIntyre Roger S
Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Obes Res Clin Pract. 2017 Jan-Feb;11(1):1-10. doi: 10.1016/j.orcp.2016.07.003. Epub 2016 Aug 4.
Depression and obesity are both highly prevalent and are leading public health problems. These foregoing disorders independently have great impact on morbidity and mortality affecting patients' health and well-being as well as on the socioeconomic aspect of functional impairment and healthcare expenditure. Results from epidemiological studies, clinical trials and recent meta-analyses support the association between mood disorders and obesity as both frequently co-occur in all races of populations examined. It is now well-established through longitudinal studies that obesity is a risk factor for mood disorders and vice versa. In the current review, we aim to address the evidence regarding 4 questions: (1) does obesity moderate response to antidepressants among patients with depressive disorders?, (2) does the presence of depressive disorders moderate the progression or outcome of obesity?, (3) does treatment of obesity moderate outcomes among patients with depressive disorders?, and (4) does treatment of depressive disorders moderate outcomes of obesity? In order to improve the interpretability of the results we confined the evaluations to studies where patients met the criteria for depressive disorders or obesity (i.e. BMI>30). Extant evidence supports the association between obesity and adverse health outcomes among individuals with depressive disorders. In addition, the treatment of one condition (i.e. obesity or depressive disorders) appears to improve the course of the other condition. It might be beneficial to check for the other condition in patients presenting with one condition and treatment should be administered to treat both conditions.
抑郁症和肥胖症都极为普遍，是主要的公共卫生问题。上述疾病各自对发病率和死亡率有重大影响，影响患者的健康和福祉，以及功能障碍和医疗支出的社会经济层面。流行病学研究、临床试验和近期的荟萃分析结果支持情绪障碍与肥胖症之间的关联，因为在所有接受调查的种族人群中，二者经常同时出现。通过纵向研究现已明确，肥胖是情绪障碍的一个危险因素，反之亦然。在当前的综述中，我们旨在探讨关于四个问题的证据：（1）肥胖是否会影响抑郁症患者对抗抑郁药的反应？（2）抑郁症的存在是否会影响肥胖症的进展或结局？（3）肥胖症的治疗是否会影响抑郁症患者的结局？（4）抑郁症的治疗是否会影响肥胖症的结局？为了提高结果的可解释性，我们将评估局限于患者符合抑郁症或肥胖症标准（即BMI>30）的研究。现有证据支持抑郁症患者中肥胖与不良健康结局之间的关联。此外，对一种疾病（即肥胖症或抑郁症）的治疗似乎会改善另一种疾病的病程。对患有其中一种疾病的患者检查是否患有另一种疾病可能有益，并且应该同时对两种疾病进行治疗。
