Ibos Guilhem, Freedman David J
Department of Neurobiology, The University of Chicago, Chicago, IL 60637, USA.
Department of Neurobiology, The University of Chicago, Chicago, IL 60637, USA; Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, The University of Chicago, Chicago, IL 60637, USA.
Neuron. 2016 Aug 17;91(4):931-943. doi: 10.1016/j.neuron.2016.07.025. Epub 2016 Aug 4.
Lateral intraparietal (LIP) neurons encode a vast array of sensory and cognitive variables. Recently, we proposed that the flexibility of feature representations in LIP reflect the bottom-up integration of sensory signals, modulated by feature-based attention (FBA), from upstream feature-selective cortical neurons. Moreover, LIP activity is also strongly modulated by the position of space-based attention (SBA). However, the mechanisms by which SBA and FBA interact to facilitate the representation of task-relevant spatial and non-spatial features in LIP remain unclear. We recorded from LIP neurons during performance of a task that required monkeys to detect specific conjunctions of color, motion direction, and stimulus position. Here we show that FBA and SBA potentiate each other's effect in a manner consistent with attention gating the flow of visual information along the cortical visual pathway. Our results suggest that linear bottom-up integrative mechanisms allow LIP neurons to emphasize task-relevant spatial and non-spatial features.
顶内沟外侧（LIP）神经元编码大量的感觉和认知变量。最近，我们提出，LIP中特征表征的灵活性反映了由基于特征的注意力（FBA）从上游特征选择性皮层神经元对感觉信号进行的自下而上的整合。此外，LIP活动也受到基于空间的注意力（SBA）位置的强烈调节。然而，SBA和FBA相互作用以促进LIP中与任务相关的空间和非空间特征表征的机制仍不清楚。我们在猴子执行一项需要检测颜色、运动方向和刺激位置的特定组合的任务期间记录了LIP神经元的活动。在这里，我们表明FBA和SBA以与注意力控制沿皮层视觉通路的视觉信息流一致的方式相互增强彼此的作用。我们的结果表明，线性自下而上的整合机制使LIP神经元能够强调与任务相关的空间和非空间特征。
