OTUD7B和NIK在非小细胞肺癌中的表达：与临床病理特征的关联及预后意义

OTUD7B and NIK expression in non-small cell lung cancer: Association with clinicopathological features and prognostic implications.

作者信息

Zhang Boxiang, Wang Huangzhen, Yang Litao, Zhang Yiwen, Wang Peili, Huang Guanghong, Zheng Jie, Ren Hong, Qin Sida

机构信息

Department Two of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.

Clinical Research Center,the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, PR China.

出版信息

Pathol Res Pract. 2016 Oct;212(10):893-898. doi: 10.1016/j.prp.2016.07.011. Epub 2016 Jul 25.

DOI:10.1016/j.prp.2016.07.011

PMID:27499151

Abstract

PURPOSE

To investigate the correlation among OTUD7B and NIK expression and the clinicopathological characteristics in NSCLC patients.

METHODS

One hundred and twenty patients were involved in this study. We detected OTUD7B and NIK expression by immunohistochemistry and analyzed their correlation with clinicopathological data.

RESULTS

The expression of OTUD7B and NIK were negatively correlated in NSCLC tumor samples (r=-0.421, P<0.001). The higher expression of OTUD7B was associated with smaller tumor size(P=0.018), less lymph node metastasis (P=0.012) and earlier TNM stage(P=0.039), while the higher expression of NIK was only related to more lymph node metastasis(P=0.031) and later TNM stage(P=0.011). MMP-9 was negatively correlated with OTUD7B and positively correlated with NIK. In addition, the high expression of OTUD7B was associated with good prognosis of NSCLC patients (log-rank=6.714, P=0.0096), and a high OTUD7B/low NIK index can predict an even better prognosis (log-rank=11.794, P=0.0006). Moreover, the multivariate Cox regression analysis showed that OTUD7B rather than NIK is an independent marker of overall survival in NSCLC patients(HR=1.602, 95% CI 1.009-2.544, P=0.046).

CONCLUSIONS

OTUD7B and NIK may play important roles in the development of lung cancer. The combination of OTUD7B and NIK expression may be a good index for predicting the prognosis of NSCLC.

摘要

目的

探讨OTUD7B和NIK表达与非小细胞肺癌（NSCLC）患者临床病理特征之间的相关性。

方法

本研究纳入120例患者。我们通过免疫组织化学检测OTUD7B和NIK表达，并分析它们与临床病理数据的相关性。

结果

NSCLC肿瘤样本中OTUD7B和NIK的表达呈负相关（r = -0.421，P < 0.001）。OTUD7B表达越高，与肿瘤体积越小（P = 0.018）、淋巴结转移越少（P = 0.012）及TNM分期越早（P = 0.039）相关，而NIK表达越高仅与更多的淋巴结转移（P = 0.031）和更晚的TNM分期（P = 0.011）相关。基质金属蛋白酶-9（MMP-9）与OTUD7B呈负相关，与NIK呈正相关。此外，OTUD7B高表达与NSCLC患者的良好预后相关（对数秩检验= 6.714，P = 0.0096），高OTUD7B/低NIK指数可预测更好的预后（对数秩检验= 11.794，P = 0.0006）。而且，多因素Cox回归分析显示，OTUD7B而非NIK是NSCLC患者总生存的独立标志物（风险比= 1.602，95%可信区间1.009 - 2.544，P = 0.046）。