Bleyer W A, Pizzo P A, Spence A M, Platt W D, Benjamin D R, Kolins C J, Poplack D G
Cancer. 1978 Jun;41(6):2431-7. doi: 10.1002/1097-0142(197806)41:6<2431::aid-cncr2820410650>3.0.co;2-3.
Two of 27 patients treated with intraventricular chemotherapy via an Ommaya reservoir developed unusual life-threatening complications attributable to the reservoir. In one patient treated for meningeal Burkitt's lymphoma, the cause of death was a large mass of tumor cells growing around the cannula. Also the tip of the cannula was found in the contralateral cerebral peduncle. In the other patient, the tip of the cannula apparently perforated the ventricular wall postoperatively and migrated into the contralateral thalamus. In both cases evidence for methotrexate-associated leukoencephalopathy was present at autopsy. Based on the experience with these two patients, we offer specific recommendations for reservoir insertion and use.
通过奥马亚贮液器进行脑室内化疗的27例患者中有2例出现了归因于该贮液器的异常且危及生命的并发症。在1例接受脑膜伯基特淋巴瘤治疗的患者中，死亡原因是插管周围生长的大量肿瘤细胞团。此外，插管尖端位于对侧脑桥。在另1例患者中，插管尖端术后显然穿破脑室壁并移入对侧丘脑。在这两例病例中，尸检均发现有甲氨蝶呤相关的白质脑病证据。基于这2例患者的经验，我们对贮液器的插入和使用提出了具体建议。
