Mathé G, Misset J L, De Vassal F, Gouveia J, Hayat M, Machover D, Belpomme D, Pico J L, Schwarzenberg L, Ribaud P, Musset M, Jasmin C, De Luca L
Cancer Treat Rep. 1978 May;62(5):805-9.
Vindesine, an analog of vinblastine and vincristine, has been submitted to a phase II trial, the results of which are judged in terms of remission induction. A high proportion of remissions were obtained in acute lymphoid leukemia and blastic crisis of chronic myeloid leukemia, and a few responses have been registered in lymphosarcoma and Hodgkin's disease. A continuous 48-hour iv infusion may induce a remission where an iv push of the same dose has failed. The most remarkable characteristic of vindesine is the absence of cross-resistance with vincristine as documented in acute lymphoid leukemia.
