Maraninchi D, Gastaut J A, Tubiana N, Carcassonne Y
Bull Cancer. 1981;68(4):338-42.
Vindesine is a semisynthetic vinca alkaloïd. The short plasma half-life suggested that continuous infusion can improve the therapeutic results by maintaining a constant plasma level. Twenty one patients (acute lymphoblastic leukemia = 5 cases; blastic crisis of chronic myelocytic leukemia = 6 cases; lymphomas 10 cases) received 5-day Vindesine infusion (0,7 mg/m2/d). All these patients had previously several treatments and were resistant to usual chemotherapies including other vinca alkaloids (76% of cases). Eighteen patients were evaluable for response: 13 (72%) had partial responses or minor regressions. Toxicity was not important. Continuous 5-day infusion of Vindesine might be used widely in patients with blood diseases.
长春地辛是一种半合成的长春花生物碱。其较短的血浆半衰期表明持续输注可通过维持恒定的血浆水平来提高治疗效果。21例患者（急性淋巴细胞白血病5例；慢性粒细胞白血病急变期6例；淋巴瘤10例）接受了为期5天的长春地辛输注（0.7mg/m²/天）。所有这些患者此前均接受过多种治疗，且对包括其他长春花生物碱在内的常规化疗耐药（76%的病例）。18例患者可评估疗效：13例（72%）有部分缓解或轻度消退。毒性并不严重。持续5天输注长春地辛可能在血液病患者中广泛应用。
