Vagner R I, Barchuk A S, Kanaev S V, Velibekov V S, Baĭkova V S
Vopr Onkol. 1989;35(6):721-6.
The study discusses the results of treatment in 118 radically operated lung cancer patients: surgery alone--66 and combined therapy including preoperative irradiation (4 Gy for 5 successive days, total focal dose--20 Gy)--52 cases. Radiation treatment did not significantly affect the patient's general condition, nor did it interfere with surgical procedure, increase operative blood loss or postoperative lethality. However, the postoperative complication rate was higher in the radiotherapy group (51.9 +/- 6.9%) than in the surgery alone group (39.4 +/- 6.0%) mainly due to increased incidence of cardiovascular disorders in patient older than 55 years of age suffering heart pathology. Radiation treatment assured a higher 5-year survival rate (32.0 +/- 9.2% as compared to 14.2 +/- 5.7%) in squamous-cell lung cancer. The beneficial effect of irradiation was most apparent in cases of central squamous-cell lung cancer with intact regional lymph nodes.
该研究探讨了118例接受根治性手术的肺癌患者的治疗结果：单纯手术治疗66例，联合治疗（包括术前放疗，连续5天，每天4 Gy，总局部剂量20 Gy）52例。放射治疗对患者的一般状况无显著影响，也未干扰手术过程、增加术中失血量或术后死亡率。然而，放疗组的术后并发症发生率（51.9±6.9%）高于单纯手术组（39.4±6.0%），主要是因为年龄超过55岁且患有心脏疾病的患者心血管疾病发生率增加。放射治疗使鳞状细胞肺癌的5年生存率更高（32.0±9.2%，而单纯手术组为14.2±5.7%）。放疗的有益效果在中央型鳞状细胞肺癌且区域淋巴结完整的病例中最为明显。
