Dobrovolśkiĭ S R, Grigoréva S P, Ivanov A N, Fishkova Z P
Khirurgiia (Mosk). 1994 Jun(6):13-7.
Combined treatment (radiotherapy--operation) was conducted in 378 patients with lung carcinoma in 1963-1991. Retrospective analysis of the immediate and late-term results of treatment showed that preoperative radiotherapy does not complicate the operative intervention. The incidence of postoperative complications is a little higher than among nonirradiated patients. Pyoinflammatory complications prevailed. Marked postradiation damage of the tumor occurred approximately in 1/3 of the patients and depended on the total largest dose of radiotherapy. Adenocarcinoma of the lung was most resistant to radiotherapy, squamous cell carcinoma and undifferentiated carcinoma were most sensitive. Total 5-year survival of patients with lung carcinoma was 35.8% after combined treatment and 42.9% after radical operations. Among patients with complete regression of the tumor after preoperative radiotherapy 63.2% of patients who underwent operation had a survival period of over 5 years.
1963年至1991年期间，对378例肺癌患者进行了综合治疗（放疗-手术）。对治疗的近期和远期结果进行回顾性分析表明，术前放疗不会使手术干预复杂化。术后并发症的发生率略高于未接受放疗的患者。脓性炎症并发症最为常见。约1/3的患者出现明显的放疗后肿瘤损伤，这取决于放疗的总最大剂量。肺腺癌对放疗最具抗性，鳞状细胞癌和未分化癌最敏感。综合治疗后肺癌患者的5年总生存率为35.8%，根治性手术后为42.9%。在术前放疗后肿瘤完全消退的患者中，接受手术的患者中有63.2%生存期超过5年。
