Khan Ayesha, Kalaria Raj N, Corbett Anne, Ballard Clive
Wolfson Centre for Age Related Diseases, Guys Campus, London, United Kingdom of Great Britain and Northern Ireland Institute of NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA.
Institute for Ageing and Health, Wolfson Research Centre, Campus for Ageing & Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom.
J Geriatr Psychiatry Neurol. 2016 Sep;29(5):281-301. doi: 10.1177/0891988716654987.
Vascular dementia (VaD) is a major contributor to the dementia syndrome and is described as having problems with reasoning, planning, judgment, and memory caused by impaired blood flow to the brain and damage to the blood vessels resulting from events such as stroke. There are a variety of etiologies that contribute to the development of vascular cognitive impairment and VaD, and these are often associated with other dementia-related pathologies such as Alzheimer disease. The diagnosis of VaD is difficult due to the number and types of lesions and their locations in the brain. Factors that increase the risk of vascular diseases such as stroke, high blood pressure, high cholesterol, and smoking also raise the risk of VaD. Therefore, controlling these risk factors can help lower the chances of developing VaD. This update describes the subtypes of VaD, with details of their complex presentation, associated pathological lesions, and issues with diagnosis, prevention, and treatment.
血管性痴呆(VaD)是导致痴呆综合征的主要原因之一,其特征是由于大脑血流受损以及中风等事件导致血管受损,进而出现推理、规划、判断和记忆方面的问题。导致血管性认知障碍和VaD发生的病因多种多样,且这些病因通常与其他痴呆相关的病理状况(如阿尔茨海默病)有关。由于大脑中病变的数量、类型及其位置,VaD的诊断较为困难。中风、高血压、高胆固醇和吸烟等增加血管疾病风险的因素也会提高患VaD的风险。因此,控制这些风险因素有助于降低患VaD的几率。本更新内容描述了VaD的亚型,详细介绍了其复杂的临床表现、相关的病理病变以及诊断、预防和治疗方面的问题。