Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Sci Rep. 2016 Aug 9;6:31264. doi: 10.1038/srep31264.
Our previous work implied that interleukin 6 (IL6) may be a biological marker for major depressive disorder (MDD). In this study, we performed a comprehensive genetic study to determine the association between the gene encoding IL6 (IL6) and MDD in Han Chinese. There were 50 drug-naïve MDD patients and 50 healthy controls undergoing an mRNA expression study. A sample of 772 patients with MDD and 759 healthy controls were used for genetic analysis. Next, we performed an eQTL analysis to identify whether risk SNP(s) is associated with IL6 expression in brain. Our results showed that patients with MDD have higher levels of IL6 than healthy controls (P = 0.008). The SNP rs1800797 has a significant association with MDD (P = 0.01) in a dominant model. The eQTL analysis showed a marginally significant association between the rs1800797 and IL6 expression in the frontal cortex (P = 0.087). Our preliminary findings are suggestive of an association between rs1800797 and the risk of MDD. Further investigations are required to evaluate this association in larger samples to increase statistical power, and to examine the correlation between rs1800797 and IL6 methylation patterns.
我们之前的工作表明白细胞介素 6（IL6）可能是重度抑郁症（MDD）的生物标志物。在这项研究中，我们进行了一项全面的遗传研究，以确定编码白细胞介素 6（IL6）的基因与汉族人群中 MDD 之间的关联。对 50 名未经药物治疗的 MDD 患者和 50 名健康对照者进行了 mRNA 表达研究。对 772 名 MDD 患者和 759 名健康对照者的样本进行了遗传分析。接下来，我们进行了 eQTL 分析，以确定风险 SNP 是否与大脑中 IL6 表达相关。我们的结果表明，与健康对照组相比，MDD 患者的 IL6 水平更高（P=0.008）。在显性模型中，SNP rs1800797 与 MDD 具有显著相关性（P=0.01）。eQTL 分析显示 rs1800797 与额叶皮质中 IL6 表达之间存在边缘显著相关性（P=0.087）。我们的初步发现提示 rs1800797 与 MDD 风险之间存在关联。需要进一步的研究来评估在更大的样本中评估这种关联，以增加统计效力，并检查 rs1800797 与 IL6 甲基化模式之间的相关性。
