Center for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland.
Medical Research Center Oulu (MRC Oulu), Oulu, Finland.
Genes Immun. 2016 Apr;17(3):193-8. doi: 10.1038/gene.2016.8. Epub 2016 Mar 3.
Interleukin 6 (IL6) is an inflammatory cytokine that has been suggested to have an important role in the pathogenesis of asthma. IL6 single-nucleotide polymorphisms (SNPs) have been associated with levels of IL6, and with childhood and prevalent adult asthma. A recent study also suggested that IL6 SNPs associate especially with atopic asthma. However, association of IL6 SNPs with adult-onset asthma has not been studied. In a population-based study of 467 incident adult-onset asthma cases and 613 disease-free controls from South Finland, we analyzed association of 6 tagging SNPs of the IL6 locus with the risk of adult-onset asthma and with atopy. Asthma was clinically diagnosed, and atopy was defined based on Phadiatop test. IL6 SNP rs1800797 associated with the risk of adult-onset asthma in a log additive model, with adjusted odds ratio (aOR) 1.31 (95% confidence interval 1.09-1.57), and especially with the risk of atopic adult-onset asthma when compared with non-atopic controls, aOR 1.46 (95% CI 1.12-1.90). This is the first study to show an association of IL6 with adult-onset asthma, and especially with atopic adult-onset asthma.
白细胞介素 6（IL6）是一种炎症细胞因子，它被认为在哮喘的发病机制中起着重要作用。IL6 单核苷酸多态性（SNP）与 IL6 水平以及儿童期和成年期普遍存在的哮喘有关。最近的一项研究还表明，IL6 SNP 尤其与特应性哮喘有关。然而，IL6 SNP 与成人发病哮喘的相关性尚未得到研究。在一项来自芬兰南部的基于人群的 467 例新发成人发病哮喘病例和 613 例无疾病对照的研究中，我们分析了 IL6 基因座的 6 个标记 SNP 与成人发病哮喘风险和特应性的相关性。哮喘是临床诊断的，特应性是根据 Phadiatop 测试定义的。IL6 SNP rs1800797 在对数相加模型中与成人发病哮喘的风险相关，调整后的优势比（aOR）为 1.31（95%置信区间 1.09-1.57），与非特应性对照组相比，特应性成人发病哮喘的风险尤其增加，aOR 为 1.46（95%CI 1.12-1.90）。这是第一项表明 IL6 与成人发病哮喘，特别是与特应性成人发病哮喘相关的研究。
