Ma Xuelei, Liu Rongjun, Zhu Chenjing, Zhang Jing, Ling Wenwu
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China, Department of Oncology, West China Hospital, Sichuan University, Chengdu, China, Collaborative Innovation Center for Biotherapy, Chengdu, China
West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
J Ultrasound Med. 2016 Oct;35(10):2095-102. doi: 10.7863/ultra.15.10005. Epub 2016 Aug 8.
The purpose of this study was to systematically review and evaluate the diagnostic accuracy of contrast-enhanced sonography in the differential diagnosis of benign and malignant breast lesions.
The scientific literature databases PubMed and Embase were comprehensively searched for relevant studies before January 2015. Data were pooled to yield the summary sensitivity, specificity, and diagnostic odds ratio using meta-analysis software.
A total of 29 studies with 2296 lesions were included in the analysis. The pooled sensitivity and specificity were 0.88 (95% confidence interval [CI], 0.86-0.90; inconsistency index [I(2)] = 77.9%) and 0.80 (95% CI, 0.78-0.83; I(2) = 84.0%), respectively. The pooled diagnostic odds ratio was 30.35 (95% CI, 15.75-58.48; I(2)= 82.1%), and the area under the summary receiver operating characteristic curve was 0.9115 (SE, 0.0243).
The comprehensive results suggest that contrast-enhanced sonography could be a potentially effective method for differential diagnosis of benign and malignant breast lesions.
本研究旨在系统评价和评估超声造影在乳腺良恶性病变鉴别诊断中的诊断准确性。
全面检索科学文献数据库PubMed和Embase，查找2015年1月之前的相关研究。使用荟萃分析软件汇总数据，得出汇总敏感性、特异性和诊断比值比。
共有29项研究、2296个病灶纳入分析。汇总敏感性和特异性分别为0.88（95%置信区间[CI]，0.86 - 0.90；不一致指数[I(2)] = 77.9%）和0.80（95% CI，0.78 - 0.83；I(2) = 84.0%）。汇总诊断比值比为30.35（95% CI，15.75 - 58.48；I(2)= 82.1%），汇总受试者工作特征曲线下面积为0.9115（标准误，0.0243）。
综合结果表明，超声造影可能是乳腺良恶性病变鉴别诊断的一种潜在有效方法。
