Wu Tao, Feng Jin-Chun, Tuerhong Shabier, Wang Bin, Yang Liang, Zhao Qian, Dilixiati Jinsihan, Xu Wen-Ting, Zhu Li-Ping
Department of Breast Oncology, Cancer Institute & Hospital of Xinjiang province, No.3 Affiliated Hospital of Xinjiang Medical University, Urumchi, Xinjiang, China.
J Ultrasound Med. 2017 Mar;36(3):485-492. doi: 10.7863/ultra.16.03063. Epub 2017 Jan 29.
The purpose of this study was to assess the diagnostic performance of ultrasound-guided diffuse optical tomography for differentiation of benign and malignant breast lesions.
The Cochrane Library, PubMed, and Embase databases were searched from inception to February 14, 2016. Sensitivity, specificity, and other information were extracted from the included studies. Sensitivity and specificity were pooled by a bivariate mixed-effects binary regression model. A summary receiver operating characteristic curve was constructed. Heterogeneity and publication bias were explored by Higgins and Deeks tests, respectively.
Seven studies including 768 women with 886 lesions were analyzed. The summary sensitivity, specificity, and diagnostic odds ratio were 95% (95% confidence interval [CI], 85%-98%), 77% (95% CI, 66%-85%), and 57 (95% CI, 12-267), respectively. The area under the summary receiver operating characteristic curve was 91% (95% CI, 89%-94%). No significant heterogeneity or publication bias existed.
Ultrasound-guided diffuse optical tomography is useful for differentiating breast lesions. Especially, its sensitivity is excellent.
本研究旨在评估超声引导下扩散光学断层扫描对乳腺良恶性病变的诊断性能。
检索Cochrane图书馆、PubMed和Embase数据库，检索时间从建库至2016年2月14日。从纳入研究中提取敏感性、特异性及其他信息。采用双变量混合效应二元回归模型合并敏感性和特异性。构建汇总受试者工作特征曲线。分别采用Higgins检验和Deeks检验探讨异质性和发表偏倚。
分析了7项研究，共768例女性患者，886个病变。汇总敏感性、特异性和诊断比值比分别为95%（95%置信区间[CI]，85%-98%）、77%（95%CI，66%-85%）和57（95%CI，12-267）。汇总受试者工作特征曲线下面积为91%（95%CI，89%-94%）。不存在显著的异质性或发表偏倚。
超声引导下扩散光学断层扫描对鉴别乳腺病变有用。尤其是，其敏感性极佳。
