光动力疗法治疗3例难治性斑块期蕈样肉芽肿的临床疗效观察

Observation of clinical efficacy of photodynamic therapy in 3 patients with refractory plaque-stage mycosis fungoides.

作者信息

Han Dawei, Xue Jingwen, Wang Tao, Liu Yuehua

机构信息

Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Bejing, 100730, China.

School of Medicine, Tsinghua University, Beijing, 100084, China.

出版信息

Photodiagnosis Photodyn Ther. 2016 Dec;16:9-11. doi: 10.1016/j.pdpdt.2016.07.011. Epub 2016 Aug 5.

DOI:10.1016/j.pdpdt.2016.07.011

PMID:27503781

Abstract

Mycosis fungoides (MF) is one of the most common cutaneous T cell lymphomas (CTCLs). Currently there are a variety of treatment methods for early-stage MF, most of which are effective. However, some lesions in plaque-stage react poorly to conventional therapy. We chose 3 patients with plaque-stage MF who failed routine therapy, to perform 2-3 times Aminolaevulinic acid-based photodynamic therapy (ALA-PDT). And it turned out that these patients responded well to ALA-PDT: the skin lesions of 2 patients subsided completely, and the last one had more than 75% of the lesions eliminated. In conclusion, compared with traditional therapy, ALA-PDT had tremendous therapeutic effect on refractory plaque-stage MF, with advantages of less side effects and quicker recovery. Therefore, ALA-PDT was an effective method for treating refractory plaque-stage MF.

摘要

蕈样肉芽肿（MF）是最常见的皮肤T细胞淋巴瘤（CTCL）之一。目前，早期MF有多种治疗方法，其中大多数都有效。然而，斑块期的一些病变对传统治疗反应不佳。我们选择了3例斑块期MF患者，他们常规治疗失败，进行了2-3次基于氨基乙酰丙酸的光动力疗法（ALA-PDT）。结果发现这些患者对ALA-PDT反应良好：2例患者的皮肤病变完全消退，最后1例患者超过75%的病变被消除。总之，与传统治疗相比，ALA-PDT对难治性斑块期MF有巨大的治疗效果，具有副作用少、恢复快的优点。因此，ALA-PDT是治疗难治性斑块期MF的有效方法。