Department of Dermatology, Kosin University College of Medicine, Busan, 602-702, Korea.
Acta Derm Venereol. 2012 May;92(3):264-8. doi: 10.2340/00015555-1261.
Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. There are a wide range of treatments for early-stage and advanced-stage mycosis fungoides. Photodynamic therapy (PDT) has emerged as a new treatment modality due to its safety and efficacy. The aim of this study was to investigate the safety and efficacy of PDT with methyl-aminolaevulinic acid (MAL) for the treatment of mycosis fungoides. Ten patients with mycosis fungoides were enrolled in this study. A 16.8% MAL cream was applied under occlusive dressing for 3 h. The lesion was irradiated at 37.5 J/cm2 with red light. The patients underwent two sessions of PDT at one-week intervals. Follow-up biopsy was performed 3 months after the last treatment. In case of partial response, treatment was repeated once a week until complete response. Seven patients had a good therapeutic response. Complete and partial responses were seen in 5 and 2 patients, respectively. During the follow-up period (8-31 months), 6 of the 7 patients remained in stable remission. The treatment was well-tolerated overall, and no patients discontinued the PDT due to pain. In conclusion, PDT with MAL is a fast, effective and well-tolerated treatment for unilesional mycosis fungoides.
蕈样肉芽肿是最常见的皮肤 T 细胞淋巴瘤。早期和晚期蕈样肉芽肿有多种治疗方法。光动力疗法（PDT）因其安全性和有效性而成为一种新的治疗方式。本研究旨在探讨 5-氨基酮戊酸（MAL）光动力疗法治疗蕈样肉芽肿的安全性和疗效。本研究纳入 10 例蕈样肉芽肿患者。在闭塞性敷料下应用 16.8% MAL 乳膏 3 h。用红光在 37.5 J/cm2 下对病灶进行照射。患者在间隔一周的时间内进行两次 PDT 治疗。末次治疗后 3 个月进行随访活检。如果部分缓解，治疗将每周重复一次，直到完全缓解。7 例患者有良好的治疗反应。5 例患者完全缓解，2 例患者部分缓解。在随访期间（8-31 个月），7 例患者中有 6 例保持稳定缓解。总体而言，治疗耐受性良好，没有患者因疼痛而停止 PDT。总之，MAL 光动力疗法是一种快速、有效且耐受性良好的治疗单发性蕈样肉芽肿的方法。
