Seyed Jafari S Morteza, Cazzaniga Simone, Hunger Robert E
Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Centro Studi GISED, Bergamo, Italy.
G Ital Dermatol Venereol. 2018 Dec;153(6):827-832. doi: 10.23736/S0392-0488.18.05977-1. Epub 2018 Apr 19.
Mycosis fungoides is the most common cutaneous T cell lymphoma. Selection of appropriate treatment for mycosis fungoides (MF) is based on prognostic factors and overall clinical stage at diagnosis. In the past decade, clinical success has been reported using photodynamic therapy (PDT) as an alternative target-specific therapy to treat mycosis fungoides. This review aimed to summarize the current advances in management of mycosis fungoides by administration of photodynamic therapy.
Twenty-four articles, published between 1994 and 2017, were reviewed to assess the efficacy of PDT for MF.
Methyl-aminolevulinic acid has increased lipophilic properties; red light at around 630 nm achieves deepest and best tissue penetration. However, the total number of PDT sessions depends on the clinical response.
Further multicenter clinical studies are warranted to assess the cost-effectiveness of PDT.
蕈样肉芽肿是最常见的皮肤T细胞淋巴瘤。蕈样肉芽肿（MF）的适当治疗选择基于预后因素和诊断时的总体临床分期。在过去十年中，有报道称使用光动力疗法（PDT）作为一种替代的靶向特异性疗法治疗蕈样肉芽肿取得了临床成功。本综述旨在总结通过光动力疗法治疗蕈样肉芽肿的当前进展。
回顾了1994年至2017年间发表的24篇文章，以评估PDT治疗MF的疗效。
甲基氨基酮戊酸具有增加的亲脂性；630nm左右的红光可实现最深且最佳的组织穿透。然而，PDT疗程的总数取决于临床反应。
有必要进行进一步的多中心临床研究以评估PDT的成本效益。
