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血清阴性系统性硬化症：一种罕见的表现。

Sero-Negative Systemic Sclerosis: A Rare Presentation.

作者信息

Chander Rakesh, Singh Santokh, Kalantri Siddhesh Arun, Charan Shiv, Gupta Abhishek

机构信息

Assistant Professor, Department of Medicine, Government Medical College , Amritsar, India .

Principal and Head, Department of Medicine, Government Medical College , Amritsar, India .

出版信息

J Clin Diagn Res. 2016 Jun;10(6):OD12-3. doi: 10.7860/JCDR/2016/16780.7973. Epub 2016 Jun 1.

DOI:10.7860/JCDR/2016/16780.7973
PMID:27504337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4963697/
Abstract

Systemic Sclerosis is a multisystem disease associated with progressive fibrosis of skin and internal organs. It is diagnosed by presence of characteristic clinical findings and is supported by specific serologic abnormalities. ANA is positive in case of systemic sclerosis in 90 percent of cases. We report a rare case of this rare disease where patient was ANA, Antitopoisomerase I (anti-Scl-70), Anticenteromere antibody negative.

摘要

系统性硬化症是一种与皮肤和内脏器官进行性纤维化相关的多系统疾病。它通过特征性临床表现来诊断，并由特定的血清学异常来支持。在系统性硬化症病例中，90%的患者抗核抗体呈阳性。我们报告了一例这种罕见疾病的罕见病例，该患者抗核抗体、抗拓扑异构酶I（抗Scl - 70）、抗着丝点抗体均为阴性。

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Arthritis Res Ther. 2019 Jun 24;21(1):152. doi: 10.1186/s13075-019-1931-x.

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Antinuclear antibody-negative systemic sclerosis.抗核抗体阴性的系统性硬化症
Semin Arthritis Rheum. 2015 Jun;44(6):680-6. doi: 10.1016/j.semarthrit.2014.11.006. Epub 2014 Nov 28.
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