Huang M S, Colby T V, Goellner J R, Martin W J
Division of Pathology, Mayo Clinic, Rochester, MN 55905.
Acta Cytol. 1989 Jul-Aug;33(4):533-8.
Two hundred consecutive bronchoalveolar lavages (BALs) performed at Mayo Clinic were retrospectively reviewed. The BAL specimens were evaluated for nuclear enlargement, hyperchromasia and increased cytoplasmic staining density as possible cytologic markers of cytotoxic drug effects. Of the 200 patients whose lavages were examined, 178 had sufficient clinical data for study. Thirty-six BAL specimens had cytologic changes consistent with drug-induced pulmonary toxic effects. Twenty-three of the 36 patients had concurrent or subsequent lung tissue available for evaluation; 10 of the 23 showed histologic evidence of cytotoxic effects. The results indicate that BAL is a safe and useful procedure, not only for the assessment of suspected pulmonary infection in immunocompromised patients, but also for the investigation of drug-induced pulmonary disease.
对梅奥诊所连续进行的200例支气管肺泡灌洗（BAL）进行回顾性分析。评估BAL标本的细胞核增大、核染色质过深和细胞质染色密度增加等情况，将其作为细胞毒性药物作用的可能细胞学标志物。在接受灌洗检查的200例患者中，178例有足够的临床数据用于研究。36份BAL标本出现了与药物性肺毒性作用相符的细胞学改变。36例患者中有23例同时或随后有肺组织可供评估；23例中的10例显示出细胞毒性作用的组织学证据。结果表明，BAL不仅是评估免疫功能低下患者疑似肺部感染的安全有用的方法，也是调查药物性肺病的方法。
