Pezza A, De Blasio F, Rennard S I
Cattedra di Malattie dell'Apparato Respiratorio, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli.
Arch Monaldi Mal Torace. 1990 May-Jun;45(3):231-40.
Bronchoalveolar lavage (BAL) is a widely used clinical procedure. To determine if BAL could provide useful information in the detection of cancer, 850 lavages from 421 patients having BAL for a variety of indications, 50 lavages in patients with Hodgkin's disease and 20 patients with breast cancer undergoing bon marrow transplant were reviewed. BALs were performed with the technique established by Rennard and coll. in which 5 successive 20 cc aliquots are infused in a wedge position. The return from the first aliquot was processed separately from the subsequent four aliquots. Diff-Quick stained cytocentrifuge preparations and Papanicolaou stained millipore filter preparations were analyzed. Thirty-five patients had biopsy-proven lung cancer. In 24 (68.6%) of these, BAL revealed cells diagnostic of malignancy. There were no false positives. Six out of 50 Hodgkin's disease patients had Reed Sternberg cells detected on BAL, and 7/20 breast cancer patients had malignant cells on BAL prior to chemotherapy. In summary, the routine performance of BAL, an easily performed and well-tolerated procedure, may prove to be useful in the routine assessment of patients for cancer.
支气管肺泡灌洗（BAL）是一种广泛应用的临床操作。为了确定BAL在癌症检测中是否能提供有用信息，我们回顾了421例因各种适应证接受BAL的患者的850次灌洗、50例霍奇金病患者的灌洗以及20例接受骨髓移植的乳腺癌患者的灌洗。BAL采用Rennard等人建立的技术进行，即在楔形位置注入5次连续的20毫升等分试样。第一次等分试样的回收液与随后的四次等分试样分开处理。对Diff-Quick染色的细胞离心涂片和巴氏染色的微孔滤膜涂片进行分析。35例患者经活检证实患有肺癌。其中24例（68.6%）的BAL显示出可诊断恶性肿瘤的细胞。没有假阳性结果。50例霍奇金病患者中有6例在BAL中检测到里德·斯特恩伯格细胞，20例乳腺癌患者中有7例在化疗前的BAL中检测到恶性细胞。总之，BAL是一种易于操作且耐受性良好的常规操作，可能在癌症患者的常规评估中证明是有用的。
