Hofman J, Rutkowski R, Michalska I
Department of Allergology, Medical School in Białystok, Poland.
Agents Actions. 1989 Apr;27(1-2):202-4. doi: 10.1007/BF02222239.
The effects of cimetidine and ranitidine on the bronchial reactivity in the group of 10 patients with atopic bronchial asthma are presented. The patients received 800 mg of cimetidine daily for 6 days and, after a three-day interval, 300 mg of ranitidine daily for a further 6 days. Bronchial reactivity to histamine was determined before the administration of each drug and on the third and sixth days of each course of treatment. A comparison of the effect of cimetidine and ranitidine on the bronchial reactivity of the same patients revealed that after 3 days' exposure to each of the two drugs, cimetidine enhanced bronchial reactivity to a statistically (p less than 0.05) greater extent than ranitidine. Bronchial reactivity was found to increase significantly after 6 days of treatment with each of the drugs but no statistically significant differences were noted on comparing the effect of these drugs. The results seem to indicate that H2 receptor antagonists may cause bronchoconstriction in some patients with bronchial asthma. The blocking effect depends on the type of the drug used and is connected with the chemical structure of the compounds.
本文介绍了西咪替丁和雷尼替丁对10例特应性支气管哮喘患者支气管反应性的影响。患者每天服用800毫克西咪替丁，持续6天，间隔3天后，再每天服用300毫克雷尼替丁，持续6天。在服用每种药物之前以及每个疗程的第3天和第6天测定支气管对组胺的反应性。比较西咪替丁和雷尼替丁对同一患者支气管反应性的影响发现，在接触这两种药物3天后，西咪替丁比雷尼替丁在统计学上（p<0.05）更大程度地增强了支气管反应性。发现用每种药物治疗6天后支气管反应性显著增加，但比较这些药物的效果时未发现统计学上的显著差异。结果似乎表明，H2受体拮抗剂可能会导致一些支气管哮喘患者出现支气管收缩。阻断作用取决于所用药物的类型，并与化合物的化学结构有关。
