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The influence of cimetidine and ranitidine on basophil histamine release and bronchial reactivity in asthmatic patients.

作者信息

Hofman J, Michalska I, Kuczewska B, Chyrek-Borowska S

出版信息

Agents Actions. 1987 Apr;20(3-4):317-9. doi: 10.1007/BF02074701.

DOI:10.1007/BF02074701
PMID:2440285
Abstract

Anti-IgE induced histamine release from isolated basophils after Cimetidine and Ranitidine administration was evaluated in 22 patients with atopic bronchial asthma. The histamine provocation test after Ranitidine treatment in 10 patients with atopic bronchial asthma and 10 patients with peptic ulcer was also performed. Investigations in vitro revealed that Cimetidine and Ranitidine in low concentrations had an inhibitory effect whereas in concentrations of over 10(-6) M and 10(-4) M, respectively, they enhanced histamine release. Investigations in vivo after administration of Ranitidine showed that it does not cause marked changes in the bronchial reactivity in patients with bronchial asthma and any change in patients with peptic ulcer. These preliminary studies seem to suggest that in patients with atopic bronchial asthma and concomitant peptic ulcer Ranitidine is preferable to Cimetidine in the treatment of digestive tract disorders.

摘要

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引用本文的文献

1
The role of H2-receptors in bronchial reactivity in atopic asthma.H2受体在特应性哮喘支气管反应性中的作用。
Agents Actions. 1988 Apr;23(3-4):370-2. doi: 10.1007/BF02142590.
2
Comparison of the effects of cimetidine and ranitidine in histamine provocation tests in atopic asthma.西咪替丁和雷尼替丁在特应性哮喘组胺激发试验中的效果比较。
Agents Actions. 1989 Apr;27(1-2):202-4. doi: 10.1007/BF02222239.
3
Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases.

本文引用的文献

1
A method for the fluorometric assay of histamine in tissues.一种用于组织中组胺荧光测定的方法。
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2
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雷尼替丁。对其药效学、药代动力学特性以及在消化性溃疡疾病和其他相关疾病中的治疗应用的最新综述。
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Bronchial hyper-reactivity in atopic patients during H2-receptor blocker treatment.
Agents Actions. 1986 Apr;18(1-2):239-41. doi: 10.1007/BF01988030.
6
A comparison of methacholine and histamine inhalations in asthmatics.哮喘患者中甲基胆碱与组胺吸入的比较。
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7
Determinants of allergen-induced asthma: dose of allergen, circulating IgE antibody concentration, and bronchial responsiveness to inhaled histamine.变应原诱发哮喘的决定因素：变应原剂量、循环IgE抗体浓度以及支气管对吸入组胺的反应性。
Am Rev Respir Dis. 1979 Nov;120(5):1053-8. doi: 10.1164/arrd.1979.120.5.1053.
8
A simplified method for measuring basophil histamine release and blocking antibodies in hay fever patients. Basophil histamine content and cell preservation.
Acta Allergol. 1977 Jun;32(3):170-82. doi: 10.1111/j.1398-9995.1977.tb01347.x.
9
The effects of H1 and H2 antihistamines on histamine inhalation challenges in asthmatic patients.H1和H2抗组胺药对哮喘患者组胺吸入激发试验的影响。
Am Rev Respir Dis. 1979 Dec;120(6):1251-8. doi: 10.1164/arrd.1979.120.6.1251.