Procaccini Claudio, Santopaolo Marianna, Faicchia Deriggio, Colamatteo Alessandra, Formisano Luigi, de Candia Paola, Galgani Mario, De Rosa Veronica, Matarese Giuseppe
Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR) c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", 80131, Napoli, Italy.
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", 80131, Napoli, Italy.
Metabolism. 2016 Sep;65(9):1376-90. doi: 10.1016/j.metabol.2016.05.018. Epub 2016 Jun 7.
Along with the increase in life expectancy over the last century, the prevalence of age-related disorders, such as neurodegenerative diseases continues to rise. This is the case of Alzheimer's, Parkinson's, Huntington's diseases and Multiple sclerosis, which are chronic disorders characterized by neuronal loss in motor, sensory or cognitive systems. Accumulating evidence has suggested the presence of a strong correlation between metabolic changes and neurodegeneration. Indeed epidemiologic studies have shown strong associations between obesity, metabolic dysfunction, and neurodegeneration, while animal models have provided insights into the complex relationships between these conditions. In this context, hormones such as leptin, ghrelin, insulin and IGF-1 seem to play a key role in the regulation of neuronal damage, toxic insults and several other neurodegenerative processes. This review aims to presenting the most recent evidence supporting the crosstalk linking energy metabolism and neurodegeneration, and will focus on metabolic manipulation as a possible therapeutic tool in the prevention and treatment of neurodegenerative diseases.
随着上个世纪预期寿命的增加，诸如神经退行性疾病等与年龄相关疾病的患病率持续上升。阿尔茨海默病、帕金森病、亨廷顿病和多发性硬化症就是这种情况，它们是慢性疾病，其特征是运动、感觉或认知系统中的神经元丧失。越来越多的证据表明代谢变化与神经退行性变之间存在密切关联。事实上，流行病学研究表明肥胖、代谢功能障碍与神经退行性变之间存在很强的关联，而动物模型则为深入了解这些情况之间的复杂关系提供了线索。在这种背景下，诸如瘦素、胃饥饿素、胰岛素和胰岛素样生长因子-1等激素似乎在调节神经元损伤、毒性损伤及其他几种神经退行性过程中发挥关键作用。本综述旨在介绍支持能量代谢与神经退行性变之间相互作用的最新证据，并将重点关注代谢调控作为预防和治疗神经退行性疾病的一种可能治疗手段。
