IRCCS MultiMedica, 20138 Milan, Italy.
Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), 80131 Naples, Italy; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", 80131 Naples, Italy.
Neuropharmacology. 2018 Jul 1;136(Pt B):307-316. doi: 10.1016/j.neuropharm.2017.12.025. Epub 2017 Dec 15.
Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin. This article is part of the Special Issue entitled 'Metabolic Impairment as Risk Factors for Neurodegenerative Disorders.'
在过去的几十年中，预期寿命有了显著的提高。这种长寿的负面影响是与年龄相关的慢性神经退行性疾病的急剧增加，如阿尔茨海默病、帕金森病和多发性硬化症。流行病学告诉我们，这些疾病的特征性神经元丧失与代谢功能障碍之间存在着很强的相关性。本综述旨在介绍支持代谢与神经退行性变之间存在分子系统的证据，特别关注两种在代谢失衡与神经系统损伤的调节交叉对话中起关键作用的激素：瘦素和生长激素释放肽。本文是特刊题为“代谢障碍作为神经退行性疾病的危险因素”的一部分。
