Hallberg L, Rossander-Hulthén L, Gramatkovski E
Department of Medicine II, University of Göteborg, Sweden.
Am J Clin Nutr. 1989 Jul;50(1):129-35. doi: 10.1093/ajcn/50.1.129.
The unexpectedly low bioavailability in humans of elemental iron powder prompted us to search for other Fe compounds suitable for Fe fortification of flour that fulfill the two requirements of insolubility in water (due to high water content of flour) and good bioavailability in humans. Systematic studies of compatibility, solubility, and bioavailability led to this study of a microcrystalline complex ferric orthophosphate (CFOP), Fe3H8(NH4)-(PO4)6.6H2O, a well-defined compound. This compound was labeled with 59Fe, and the native Fe in meals was labeled with 55FeCl3. The ratio of absorbed 59Fe to absorbed 55Fe is a direct measure of the fraction of CFOP that joins the nonheme Fe pool and that is made potentially available for absorption. The relative bioavailability of CFOP varied from 30% to 60% when labeled wheat rolls were served with different meals. The CFOP meets practical requirements of an Fe fortificant for flour well, with regard to both compatibility and bioavailability in humans.
元素铁粉在人体中的生物利用度出乎意料地低，这促使我们寻找其他适合用于面粉铁强化的铁化合物，这些化合物要满足两个要求：在水中不溶（由于面粉含水量高）以及在人体中有良好的生物利用度。对兼容性、溶解度和生物利用度的系统研究促成了对一种微晶复合磷酸铁（CFOP），即Fe3H8(NH4)-(PO4)6.6H2O，一种明确化合物的研究。该化合物用59Fe标记，膳食中的天然铁用55FeCl3标记。吸收的59Fe与吸收的55Fe的比率是CFOP加入非血红素铁池并有可能被吸收的部分的直接衡量指标。当搭配不同膳食提供标记的小麦面包卷时，CFOP的相对生物利用度在30%至60%之间变化。就人体中的兼容性和生物利用度而言，CFOP很好地满足了面粉铁强化剂的实际要求。
