Subbiah M T, Sprinkle J D, Rymaszewski Z, Yunker R L
Department of Internal Medicine and Pathology, University of Cincinnati Medical Center, OH.
Am J Clin Nutr. 1989 Jul;50(1):68-72. doi: 10.1093/ajcn/50.1.68.
Elevated serum cholesterol is an established risk factor for the development of atherosclerosis but the effect of high dietary cholesterol in early life on subsequent arterial response to atherogenic diet in adult life is unknown. Weanling rabbits were exposed for 6 wk to a diet containing 0.25% cholesterol, allowed to recover for 9 wk (at least 3 wk after normalization of plasma cholesterol), and subsequently rechallenged with cholesterol to determine atherogenic response. Enhanced activity of acyl-CoA-cholesterol-acyl-transferase in aorta induced by cholesterol feeding persisted even after normalization of serum cholesterol. When rechallenged with cholesterol for 3 mo, these animals displayed significantly (p less than 0.05) increased development of aortic atherosclerosis and accumulation of cholesterol esters when compared with control animals. Exposure to cholesterol in early life appears to cause persistent changes in cholesterol ester synthetic enzyme activity in aorta after normalization of plasma cholesterol and these residual effects might increase aortic response to subsequent cholesterol challenge in adult life.
血清胆固醇升高是动脉粥样硬化发生的一个既定风险因素，但早年高膳食胆固醇对成年后动脉对致动脉粥样化饮食的后续反应的影响尚不清楚。将断奶兔暴露于含0.25%胆固醇的饮食6周，使其恢复9周（血浆胆固醇正常化后至少3周），随后再次用胆固醇进行激发以确定动脉粥样化反应。即使在血清胆固醇正常化后，喂食胆固醇诱导的主动脉中酰基辅酶A胆固醇酰基转移酶活性增强仍持续存在。当再次用胆固醇激发3个月时，与对照动物相比，这些动物的主动脉粥样硬化发展和胆固醇酯积累显著增加（p<0.05）。早年暴露于胆固醇似乎会在血浆胆固醇正常化后导致主动脉中胆固醇酯合成酶活性发生持续变化，这些残留效应可能会增加成年后主动脉对后续胆固醇激发的反应。
