患有不平衡der(6)t(X;6)易位的小儿t(12;21)阳性急性淋巴细胞白血病患者中受影响的癌症相关基因的数据。
Data on affected cancer-related genes in pediatric t(12;21)-positive acute lymphoblastic leukemia patients harboring unbalanced der(6)t(X;6) translocations.
作者信息
Kjeldsen Eigil
机构信息
Hemodiagnostic Laboratory, Cancer Cytogenetics Section, Department of Hematology, Aarhus University Hospital.
出版信息
Data Brief. 2016 Jul 5;8:894-903. doi: 10.1016/j.dib.2016.06.060. eCollection 2016 Sep.
Abstract
The t(12;21)(p13;q22), leading to ETV6/RUNX1 fusion, is of importance for leukemogenesis in acute lymphoblastic leukemia but is not sufficient for the leukemic transformation. Acquired secondary chromosomal aberrations are necessary for overt leukemia but their complete nature and genes involved are still elusive. In our recent publication, "Oligo-based aCGH analysis reveals cryptic unbalanced der(6)t(X;6) in pediatric t(12;21)-positive acute lymphoblastic leukemia", we identified acquired common concurrent regions with 6q deletion and Xq duplication E. Kjeldsen (2016) [1]. The present article provides data on genes that are associated with hematological malignancy and other cancers located in these common regions of chromosomal aberrations.
摘要
导致ETV6/RUNX1融合的t(12;21)(p13;q22)对急性淋巴细胞白血病的白血病发生具有重要意义，但不足以导致白血病转化。获得性继发性染色体畸变是显性白血病所必需的，但其完整性质和相关基因仍不清楚。在我们最近发表的“基于寡核苷酸的aCGH分析揭示小儿t(12;21)阳性急性淋巴细胞白血病中隐匿性不平衡der(6)t(X;6)”一文中，我们确定了伴有6号染色体长臂缺失和X染色体长臂重复的获得性共同并发区域E. 凯尔森（2016年）[1]。本文提供了位于这些染色体畸变共同区域的与血液系统恶性肿瘤和其他癌症相关的基因数据。
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本文引用的文献
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Oligo-based aCGH analysis reveals cryptic unbalanced der(6)t(X;6) in pediatric t(12;21)-positive acute lymphoblastic leukemia.基于寡核苷酸的阵列比较基因组杂交分析揭示了小儿t(12;21)阳性急性淋巴细胞白血病中隐匿的不平衡der(6)t(X;6)。
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