Fitzpatrick Nicole Edgar, Maier John, Yasko Laurel, Mathias David, Qua Kacy, Wagner Erika, Miller Elizabeth, Reis Steven E
N.E. Fitzpatrick is innovation project manager, Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania. J. Maier is assistant professor of family medicine and clinical and translational science, University of Pittsburgh, Pittsburgh, Pennsylvania. L. Yasko is administrative director of operations, Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania. D. Mathias is administrative director of finance, Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania. K. Qua is founder and chief executive officer, Qualifyor, Las Vegas, Nevada. E. Wagner is business development manager, Blue Origin, Kent, Washington. E. Miller is professor of pediatrics and clinical and translational science, University of Pittsburgh, Pittsburgh, Pennsylvania. S.E. Reis is associate vice chancellor for clinical research, health sciences, and professor of medicine and clinical and translational science, University of Pittsburgh, Pittsburgh, Pennsylvania.
Acad Med. 2017 May;92(5):671-675. doi: 10.1097/ACM.0000000000001335.
Translational research aims to move scientific discoveries across the biomedical spectrum from the laboratory to humans, and to ultimately transform clinical practice and public health policies. Despite efforts to accelerate translational research through national initiatives, several major hurdles remain.
The authors created the Pitt Innovation Challenge (PInCh) as an incentive-based, problem-focused approach to solving identified clinical or public health problems at the University of Pittsburgh Clinical and Translational Science Institute in spring 2014. With input from a broad range of stakeholders, PInCh leadership arrived at the challenge question: How do we empower individuals to take control of their own health outcomes? The authors developed the PInCh's three-round proposal submission and review process as well as an online contest management tool to support the process.
Ninety-two teams submitted video proposals in round one. Proposals included mobile applications (29; 32%), other information technology (19; 21%), and community program (22; 24%) solutions. Ten teams advanced to the final round, where three were awarded $100,000 to implement their solution over 12 months. In a 6-month follow-up survey, 6/11 (55%) team leaders stated the PInCh helped to facilitate connections outside their normal sphere of collaborators.
Additional educational training sessions related to problem-focused research will be developed. The PInCh will be expanded to engage investment and industry communities to facilitate the translation of solutions to clinical practice via commercialization pathways. External organizations and other universities will be engaged to use the PInCh as a mechanism to fuel innovation in their spaces.
转化研究旨在将生物医学领域的科学发现从实验室应用于人类,并最终改变临床实践和公共卫生政策。尽管通过国家倡议努力加速转化研究,但仍存在几个主要障碍。
作者于2014年春季在匹兹堡大学临床与转化科学研究所创建了匹兹堡创新挑战赛(PInCh),这是一种基于激励、以问题为导向的方法,用于解决已确定的临床或公共卫生问题。在广泛的利益相关者的参与下,PInCh的领导层提出了挑战问题:我们如何赋能个体掌控自己的健康结果?作者开发了PInCh的三轮提案提交和评审流程以及一个在线竞赛管理工具来支持这一过程。
第一轮有92个团队提交了视频提案。提案包括移动应用程序(29个;32%)、其他信息技术(19个;21%)和社区项目(22个;24%)解决方案。10个团队进入决赛,其中3个团队获得10万美元,用于在12个月内实施他们的解决方案。在一项为期6个月的后续调查中,11位团队负责人中有6位(55%)表示,PInCh有助于促进他们与常规合作领域之外的人建立联系。
将开展与以问题为导向的研究相关的额外教育培训课程。PInCh将扩大规模,吸引投资和行业界参与,以促进通过商业化途径将解决方案转化为临床实践。将邀请外部组织和其他大学将PInCh作为推动其领域创新的一种机制。