Ruas Luiz Gustavo, Diniz Breno S, Firmo Josélia O, Peixoto Sérgio V, Mambrini Juliana V, Loyola-Filho Antônio Ignácio de, Lima-Costa Maria Fernanda, Castro-Costa Érico
Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
Department of Psychiatry and Behavioral Sciences and Consortium on Aging, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Braz J Psychiatry. 2016 Jul-Sep;38(3):183-9. doi: 10.1590/1516-4446-2015-1856. Epub 2016 Apr 8.
To investigate the moderating effect of an increasing number of clustered metabolic syndrome (MetS) components on the association between MetS and depressive symptoms in a population-based cohort of older adults in Brazil.
This analysis used data from the Bambuí Cohort Aging Study. Participants in this cross-sectional study comprised 1,469 community-dwelling older people aged ≥ 60 years. Analyses were performed to assess both the association between depressive symptoms and each individual MetS component and the association between depressive symptoms and clustering of an increasing number of MetS components.
High triglyceride level was the individual component that showed the strongest association with depressive symptoms (odds ratio [OR]: 1.47; 95% confidence intervals [95%CI] 1.19-1.81; p < 0.0001). Only the presence of three MetS components was associated with depressive symptoms (OR = 1.53; 95%CI 1.05-2.23; p = 0.025). No graded association was detected between increasing number of clustered MetS components and depressive symptoms.
Increasing the number of MetS components did not impact the association with depressive symptoms. The association between high triglyceride level and depressive symptoms highlights the relevance of lipid metabolism abnormalities for the emergence of depressive symptoms in older adults.
在巴西一个基于人群的老年队列中，研究聚集性代谢综合征（MetS）组分数量增加对MetS与抑郁症状之间关联的调节作用。
本分析使用了班布伊队列衰老研究的数据。这项横断面研究的参与者包括1469名年龄≥60岁的社区居住老年人。进行分析以评估抑郁症状与每个单独的MetS组分之间的关联，以及抑郁症状与越来越多的MetS组分聚集之间的关联。
高甘油三酯水平是与抑郁症状关联最强的个体组分（比值比[OR]：1.47；95%置信区间[95%CI] 1.19 - 1.81；p < 0.0001）。只有存在三种MetS组分与抑郁症状相关（OR = 1.53；95%CI 1.05 - 2.23；p = 0.025）。未检测到聚集的MetS组分数量增加与抑郁症状之间存在分级关联。
MetS组分数量增加并未影响与抑郁症状的关联。高甘油三酯水平与抑郁症状之间的关联突出了脂质代谢异常在老年人抑郁症状出现中的相关性。
