Medical School, National and Kapodistrian University of Athens, Mikras Asias Street, 75, Goudi, Athens, 11527, Greece.
Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Dr Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona, 08830, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Monforte de Lemos 3-5, Pabellón 11, Madrid, 28029, Spain; Facultat de Medicina, Universitat de Barcelona, Casanova, 143, Barcelona, 08036, Spain.
J Affect Disord. 2018 Sep;237:56-64. doi: 10.1016/j.jad.2018.04.102. Epub 2018 Apr 22.
Metabolic syndrome (MetS) has been shown to be associated with depression in older adults but the results are mixed. We summarized and evaluated the association between depression and MetS in people aged 60 years or over.
Relevant published studies from January 1997 to July 2017 were identified by searching two electronic databases: PubMed/Medline and EMBASE. Observational studies were considered.
Twelve studies were included in the systematic review. Depression seemed to be related with MetS in the majority of the studies (10/12 = 83.3%). As far as the longitudinal studies are concerned, the onset of depression was related to MetS in 2 out of 3 studies (66.6%), while a relation between chronicity of depression and MetS was reported (1 study). Regarding cross-sectional studies, 7 out of 9 (77.7%) concluded that there was a positive association between depression and MetS. Mixed evidence was found among studies concerning the association between depression and the individual components of MetS. Four out of ten studies (40%) reported that depression was significantly associated with the waist circumference, a component of MetS.
There was a high degree of heterogeneity between studies regarding their design. Only studies written in English, from peer-reviewed journals were included.
Depression seemed to be significantly associated with MetS in people aged 60 years or over. Among the components of MetS, abdominal obesity seemed to be associated more strongly and consistently with depression. The direction of the causality and mechanisms underlying the relationship are still largely unknown.
代谢综合征（MetS）与老年人抑郁有关，但结果不一。我们总结和评估了 60 岁及以上人群中抑郁与 MetS 的关系。
通过检索两个电子数据库：PubMed/Medline 和 EMBASE，检索 1997 年 1 月至 2017 年 7 月期间发表的相关研究。纳入观察性研究。
12 项研究纳入系统评价。大多数研究（10/12=83.3%）表明抑郁与 MetS 有关。就纵向研究而言，3 项研究中有 2 项（66.6%）表明抑郁发作与 MetS 有关，而 1 项研究报告了抑郁的慢性与 MetS 之间的关系。关于横断面研究，9 项中有 7 项（77.7%）得出结论，抑郁与 MetS 之间存在正相关。关于抑郁与 MetS 各个成分之间关系的研究存在混合证据。10 项研究中有 4 项（40%）报告称，抑郁与 MetS 的一个组成部分腰围显著相关。
研究在设计上存在高度异质性。仅纳入了同行评审期刊发表的英语研究。
抑郁与 60 岁及以上人群的 MetS 显著相关。在 MetS 的组成部分中，腹部肥胖与抑郁的相关性更强且更一致。因果关系的方向和潜在机制在很大程度上仍不清楚。
