脑瘫患者骨骼肌纤维类型特异性琥珀酸脱氢酶活性
Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy.
作者信息
Zogby Andrew M, Dayanidhi Sudarshan, Chambers Henry G, Schenk Simon, Lieber Richard L
机构信息
School of Medicine, University of California, San Diego, California, USA.
Department of Orthopaedic Surgery, University of California, San Diego, California, USA.
出版信息
Muscle Nerve. 2017 Jan;55(1):122-124. doi: 10.1002/mus.25379. Epub 2016 Sep 26.
INTRODUCTION
Children with cerebral palsy (CP) exhibit increased energy expenditure during movement, but whether this is due in part to decrements in skeletal muscle mitochondrial oxidative capacity is unknown. Accordingly, we compared fiber-type specific succinate dehydrogenase (SDH) activity in children with CP with typically developing (TD) children.
METHODS
SDH activity and myofiber areas of type 1 and 2A fibers were measured in semitendinosus biopsies of both groups (n = 5/group).
RESULTS
SDH activity was ∼35% higher in type 1 compared with type 2A fibers, but there were no differences between groups. Average myofiber area was 45% smaller in CP versus TD (P < 0.05), and type 2A fibers were 32% larger than type 1 fibers (P < 0.05) only in TD children.
CONCLUSIONS
Fiber-type specific SDH activity is similar between TD children and children with CP. This suggests that increased energy expenditure in children with CP is not related to impaired mitochondrial oxidative capacity. Muscle Nerve, 2016 Muscle Nerve 55: 122-124, 2017.
引言
脑瘫（CP）患儿在运动过程中能量消耗增加，但这是否部分归因于骨骼肌线粒体氧化能力下降尚不清楚。因此，我们比较了脑瘫患儿与正常发育（TD）儿童纤维类型特异性琥珀酸脱氢酶（SDH）的活性。
方法
测量两组（每组n = 5）半腱肌活检标本中1型和2A型纤维的SDH活性及肌纤维面积。
结果
1型纤维的SDH活性比2A型纤维高约35%，但两组之间无差异。与TD儿童相比，CP患儿的平均肌纤维面积小45%（P < 0.05），仅在TD儿童中，2A型纤维比1型纤维大32%（P < 0.05）。
结论
TD儿童和CP患儿之间纤维类型特异性SDH活性相似。这表明CP患儿能量消耗增加与线粒体氧化能力受损无关。《肌肉与神经》，2016年 2017年《肌肉与神经》第55卷：122 - 124页
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