氢化可的松对雄性大鼠肝脏中色氨酸吡咯酶的年龄相关差异诱导作用。
Age-related differential induction of tryptophan pyrrolase by hydrocortisone in the liver of male rats.
作者信息
Patnaik S K, Patnaik R
机构信息
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
出版信息
Biochem Int. 1989 Jun;18(6):1221-8.
The activity and the regulatory pattern of tryptophan pyrrolase of the liver of male rats during various phases of the life span were studied with a view to investigate the differential effectiveness of hydrocortisone in relation to growth, development, and senescence of an organism. The level of this enzyme shows no significant change till adulthood but decreases significantly thereafter with increasing age. Adrenalectomy and hydrocortisone treatments decrease and increase, respectively the activity of this enzyme significantly in rats of all the ages. However, the effects of these treatments are highest in the mature rat. Induction of the enzyme by hydrocortisone is actinomycin D-sensitive.
为了研究氢化可的松在生物体生长、发育和衰老过程中的不同作用效果，对雄性大鼠肝脏中色氨酸吡咯酶在生命周期各阶段的活性及调节模式进行了研究。该酶水平在成年期之前无显著变化，但成年后随年龄增长显著下降。肾上腺切除术和氢化可的松处理分别使各年龄段大鼠该酶的活性显著降低和升高。然而，这些处理的效果在成熟大鼠中最为明显。氢化可的松对该酶的诱导作用对放线菌素D敏感。
Zotero 插件