Patnaik S K, Sharma R, Patnaik R
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
Biochem Int. 1987 Sep;15(3):611-7.
The activity and induction patterns of the isoenzymes of aspartate aminotransferase (AsAT) of the liver of male rats during growth, development, and senescence were studied. The activity of both the cytoplasmic and mitochondrial isoenzymes increased significantly until adulthood and remained constant thereafter. Adrenalectomy decreased, and hydrocortisone administration increased, the activity of the cytoplasmic AsAT of the liver of young-immature, adult, and senescent rats. However, the degree of these responses decreased with increasing age of the animal. The hormone-mediated induction of this isoenzyme is actinomycin D-sensitive. Mitochondrial AsAT on the other hand is irresponsive towards these treatments throughout the life span of the rat.
研究了雄性大鼠肝脏中天冬氨酸转氨酶（AsAT）同工酶在生长、发育和衰老过程中的活性及诱导模式。细胞质和线粒体同工酶的活性在成年前显著增加，此后保持恒定。肾上腺切除降低了幼年未成熟、成年和衰老大鼠肝脏细胞质AsAT的活性，而给予氢化可的松则使其活性增加。然而，这些反应的程度随动物年龄的增加而降低。这种同工酶的激素介导诱导对放线菌素D敏感。另一方面，线粒体AsAT在大鼠的整个寿命期内对这些处理均无反应。
