Halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy.
作者信息
Nadesalingam Kavitha, Goodfield Mark, Emery Paul
机构信息
Department of Rheumatology , Chapel Allerton Hospital , Leeds , UK.
Department of Dermatology , Leeds General Infirmary , Leeds , UK.
出版信息
Oxf Med Case Reports. 2016 Aug 9;2016(8):omw027. doi: 10.1093/omcr/omw027. eCollection 2016 Aug.
Abstract
We present a follow-up case report of a 33-year-old lady with juvenile onset arthritis who developed halo naevi while on treatment with tocilizumab. This case report describes the development of halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy following infection with Methicillin-resistant Staphylococcus aureus (MRSA) and Panton-Valentine leukocidin positivity. This is the first case that describes these events and supports previous theories on cellular and humoral immunity as causative factors. The regression of melanocytes during treatment with tocilizumab could also implicate IL-6 and sIL-6R as future targets in the treatment of melanoma through its direct effect of melanocytic cytotoxicity, which supports previous studies.
摘要
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