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核心技术专利：CN118964589B侵权必究

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

Walker Chloe J, Flanagan Kelly E, Pathoulas James T, Pupo Wiss Isabel, Senna Maryanne M

Department of Dermatology, Harvard Medical School-Massachusetts General Hospital, Boston, Massachusetts, USA.

Skin Appendage Disord. 2021 Aug;7(5):408-412. doi: 10.1159/000516300. Epub 2021 Jun 9.

INTRODUCTION

Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ.

CASE PRESENTATION

Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis.

DISCUSSION

Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.

引言

托珠单抗（TCZ）是一种靶向白细胞介素-6（IL-6）信号传导的重组人源化抗人单克隆抗体，常用于自身免疫性疾病的治疗。很少有报告显示使用托珠单抗的患者毛发有生长变化。

病例报告

在此，我们回顾文献并报告一名21岁患有进行性斑秃（AA）的女性，她在因并发后葡萄膜炎而使用托珠单抗治疗期间斑秃情况有所改善。

讨论

我们的病例表明托珠单抗具有破坏斑秃中涉及的IL-6信号传导的潜在能力，从而导致脱发和毛发再生。

相似文献

Hair Growth in a Patient with Alopecia Areata on Tocilizumab.使用托珠单抗治疗斑秃患者的毛发生长情况

Skin Appendage Disord. 2021 Aug;7(5):408-412. doi: 10.1159/000516300. Epub 2021 Jun 9.

Alopecia areata with white hair regrowth: case report and review of poliosis.斑秃伴白发再生：病例报告及白发症综述

Dermatol Online J. 2014 Sep 16;20(9):13030/qt1xk5b26v.

Unexpected hair regrowth in a woman with longstanding Alopecia universalis.一名患有长期全秃症的女性出现意外毛发再生。

GMS Ophthalmol Cases. 2021 May 11;11:Doc08. doi: 10.3205/oc000181. eCollection 2021.

Targetoid Hair Regrowth Pattern in Alopecia Areata: A Case Series.斑秃中的类靶形毛发再生模式：病例系列

Int J Trichology. 2023 Sep-Oct;15(5):204-207. doi: 10.4103/ijt.ijt_48_22. Epub 2024 Jul 11.

Concentric Polycyclic Regrowth Pattern in Alopecia Areata.斑秃中的同心多环再生模式。

Int J Trichology. 2016 Jan-Mar;8(1):35-7. doi: 10.4103/0974-7753.179397.

A review of monochromatic light devices for the treatment of alopecia areata.用于治疗斑秃的单色光设备综述。

Lasers Med Sci. 2018 Feb;33(2):435-444. doi: 10.1007/s10103-017-2412-6. Epub 2017 Dec 17.

Alopecia areata treated with dimethyl fumarate: A case series.用富马酸二甲酯治疗斑秃：病例系列。

Dermatol Ther. 2020 Nov;33(6):e14158. doi: 10.1111/dth.14158. Epub 2020 Sep 4.

Systemic Lupus Erythematosus Presenting as Alopecia Areata.表现为斑秃的系统性红斑狼疮

Cureus. 2020 Jun 20;12(6):e8724. doi: 10.7759/cureus.8724.

Hair Regrowth Outcomes of Contact Immunotherapy for Patients With Alopecia Areata: A Systematic Review and Meta-analysis.接触免疫疗法治疗斑秃患者的毛发再生结果：系统评价和荟萃分析。

JAMA Dermatol. 2018 Oct 1;154(10):1145-1151. doi: 10.1001/jamadermatol.2018.2312.

Childhood Alopecia Areata: An Overview of Treatment and Recent Patents.儿童斑秃：治疗概述及近期专利。

Recent Pat Inflamm Allergy Drug Discov. 2020;14(2):117-132. doi: 10.2174/1872213X14999200728145822.

引用本文的文献

The role of salivary vitamin D and interleukin-6 on non-scarring Alopecia.唾液维生素 D 和白细胞介素-6 在非瘢痕性脱发中的作用。

Arch Dermatol Res. 2024 Oct 16;316(10):695. doi: 10.1007/s00403-024-03416-z.

Recent approaches of antibody therapeutics in androgenetic alopecia.雄激素性脱发中抗体疗法的最新进展。

Front Pharmacol. 2024 Aug 16;15:1434961. doi: 10.3389/fphar.2024.1434961. eCollection 2024.

本文引用的文献

Increased Serum Levels of IFN-, IL-1, and IL-6 in Patients with Alopecia Areata and Nonsegmental Vitiligo.斑秃和非节段性白癜风患者血清 IFN-、IL-1 和 IL-6 水平升高。

Oxid Med Cell Longev. 2020 Aug 3;2020:5693572. doi: 10.1155/2020/5693572. eCollection 2020.

Hair follicle immune privilege and its collapse in alopecia areata.毛发滤泡免疫豁免及其在斑秃中的崩溃。

Exp Dermatol. 2020 Aug;29(8):703-725. doi: 10.1111/exd.14155.

Cause or cure? Review of dupilumab and alopecia areata.

J Am Acad Dermatol. 2023 Mar;88(3):651-653. doi: 10.1016/j.jaad.2019.06.010. Epub 2019 Jun 13.

An integrated model of alopecia areata biomarkers highlights both T1 and T2 upregulation.斑秃生物标志物的综合模型突出了T1和T2的上调。

J Allergy Clin Immunol. 2018 Nov;142(5):1631-1634.e13. doi: 10.1016/j.jaci.2018.06.029. Epub 2018 Jul 5.

Primary (Month-6) Outcomes of the STOP-Uveitis Study: Evaluating the Safety, Tolerability, and Efficacy of Tocilizumab in Patients With Noninfectious Uveitis.STOP-葡萄膜炎研究的主要（第6个月）结局：评估托珠单抗在非感染性葡萄膜炎患者中的安全性、耐受性和疗效。

Am J Ophthalmol. 2017 Nov;183:71-80. doi: 10.1016/j.ajo.2017.08.019. Epub 2017 Sep 5.

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.皮肤中的调节性T细胞促进上皮干细胞分化。

Cell. 2017 Jun 1;169(6):1119-1129.e11. doi: 10.1016/j.cell.2017.05.002. Epub 2017 May 25.

Halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy.托珠单抗治疗相关的晕痣、白癜风和斑秃。

Oxf Med Case Reports. 2016 Aug 9;2016(8):omw027. doi: 10.1093/omcr/omw027. eCollection 2016 Aug.

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.斑秃由细胞毒性 T 淋巴细胞驱动，并可被 JAK 抑制逆转。

Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17.

Telogen effluvium.休止期脱发。

Indian J Dermatol Venereol Leprol. 2013 Sep-Oct;79(5):591-603. doi: 10.4103/0378-6323.116731.

Hair-cycle changes in two patients taking tocilizumab.两名使用托珠单抗患者的毛发周期变化。

Joint Bone Spine. 2014 Jan;81(1):100-1. doi: 10.1016/j.jbspin.2013.07.002. Epub 2013 Aug 13.

相似文献

Hair Growth in a Patient with Alopecia Areata on Tocilizumab.使用托珠单抗治疗斑秃患者的毛发生长情况

Skin Appendage Disord. 2021 Aug;7(5):408-412. doi: 10.1159/000516300. Epub 2021 Jun 9.

Alopecia areata with white hair regrowth: case report and review of poliosis.斑秃伴白发再生：病例报告及白发症综述

Dermatol Online J. 2014 Sep 16;20(9):13030/qt1xk5b26v.

Unexpected hair regrowth in a woman with longstanding Alopecia universalis.一名患有长期全秃症的女性出现意外毛发再生。

GMS Ophthalmol Cases. 2021 May 11;11:Doc08. doi: 10.3205/oc000181. eCollection 2021.

Targetoid Hair Regrowth Pattern in Alopecia Areata: A Case Series.斑秃中的类靶形毛发再生模式：病例系列

Int J Trichology. 2023 Sep-Oct;15(5):204-207. doi: 10.4103/ijt.ijt_48_22. Epub 2024 Jul 11.

Concentric Polycyclic Regrowth Pattern in Alopecia Areata.斑秃中的同心多环再生模式。

Int J Trichology. 2016 Jan-Mar;8(1):35-7. doi: 10.4103/0974-7753.179397.

A review of monochromatic light devices for the treatment of alopecia areata.用于治疗斑秃的单色光设备综述。

Lasers Med Sci. 2018 Feb;33(2):435-444. doi: 10.1007/s10103-017-2412-6. Epub 2017 Dec 17.

Alopecia areata treated with dimethyl fumarate: A case series.用富马酸二甲酯治疗斑秃：病例系列。

Dermatol Ther. 2020 Nov;33(6):e14158. doi: 10.1111/dth.14158. Epub 2020 Sep 4.

Systemic Lupus Erythematosus Presenting as Alopecia Areata.表现为斑秃的系统性红斑狼疮

Cureus. 2020 Jun 20;12(6):e8724. doi: 10.7759/cureus.8724.

JAMA Dermatol. 2018 Oct 1;154(10):1145-1151. doi: 10.1001/jamadermatol.2018.2312.

Childhood Alopecia Areata: An Overview of Treatment and Recent Patents.儿童斑秃：治疗概述及近期专利。

Recent Pat Inflamm Allergy Drug Discov. 2020;14(2):117-132. doi: 10.2174/1872213X14999200728145822.

引用本文的文献

The role of salivary vitamin D and interleukin-6 on non-scarring Alopecia.唾液维生素 D 和白细胞介素-6 在非瘢痕性脱发中的作用。

Arch Dermatol Res. 2024 Oct 16;316(10):695. doi: 10.1007/s00403-024-03416-z.

Recent approaches of antibody therapeutics in androgenetic alopecia.雄激素性脱发中抗体疗法的最新进展。

Front Pharmacol. 2024 Aug 16;15:1434961. doi: 10.3389/fphar.2024.1434961. eCollection 2024.

本文引用的文献

Increased Serum Levels of IFN-, IL-1, and IL-6 in Patients with Alopecia Areata and Nonsegmental Vitiligo.斑秃和非节段性白癜风患者血清 IFN-、IL-1 和 IL-6 水平升高。

Oxid Med Cell Longev. 2020 Aug 3;2020:5693572. doi: 10.1155/2020/5693572. eCollection 2020.

Hair follicle immune privilege and its collapse in alopecia areata.毛发滤泡免疫豁免及其在斑秃中的崩溃。

Exp Dermatol. 2020 Aug;29(8):703-725. doi: 10.1111/exd.14155.

Cause or cure? Review of dupilumab and alopecia areata.

J Am Acad Dermatol. 2023 Mar;88(3):651-653. doi: 10.1016/j.jaad.2019.06.010. Epub 2019 Jun 13.

An integrated model of alopecia areata biomarkers highlights both T1 and T2 upregulation.斑秃生物标志物的综合模型突出了T1和T2的上调。

J Allergy Clin Immunol. 2018 Nov;142(5):1631-1634.e13. doi: 10.1016/j.jaci.2018.06.029. Epub 2018 Jul 5.

Am J Ophthalmol. 2017 Nov;183:71-80. doi: 10.1016/j.ajo.2017.08.019. Epub 2017 Sep 5.

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.皮肤中的调节性T细胞促进上皮干细胞分化。

Cell. 2017 Jun 1;169(6):1119-1129.e11. doi: 10.1016/j.cell.2017.05.002. Epub 2017 May 25.

Halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy.托珠单抗治疗相关的晕痣、白癜风和斑秃。

Oxf Med Case Reports. 2016 Aug 9;2016(8):omw027. doi: 10.1093/omcr/omw027. eCollection 2016 Aug.

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.斑秃由细胞毒性 T 淋巴细胞驱动，并可被 JAK 抑制逆转。

Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17.

Telogen effluvium.休止期脱发。

Indian J Dermatol Venereol Leprol. 2013 Sep-Oct;79(5):591-603. doi: 10.4103/0378-6323.116731.

Hair-cycle changes in two patients taking tocilizumab.两名使用托珠单抗患者的毛发周期变化。

Joint Bone Spine. 2014 Jan;81(1):100-1. doi: 10.1016/j.jbspin.2013.07.002. Epub 2013 Aug 13.

Walker Chloe J, Flanagan Kelly E, Pathoulas James T, Pupo Wiss Isabel, Senna Maryanne M

Department of Dermatology, Harvard Medical School-Massachusetts General Hospital, Boston, Massachusetts, USA.

Skin Appendage Disord. 2021 Aug;7(5):408-412. doi: 10.1159/000516300. Epub 2021 Jun 9.

INTRODUCTION

CASE PRESENTATION

Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis.

DISCUSSION

Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.

引言

病例报告

在此，我们回顾文献并报告一名21岁患有进行性斑秃（AA）的女性，她在因并发后葡萄膜炎而使用托珠单抗治疗期间斑秃情况有所改善。

讨论

我们的病例表明托珠单抗具有破坏斑秃中涉及的IL-6信号传导的潜在能力，从而导致脱发和毛发再生。

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深度研究

Suppr 超能文献

文献检索

文件翻译

深度研究

使用托珠单抗治疗斑秃患者的毛发生长情况

Hair Growth in a Patient with Alopecia Areata on Tocilizumab.

作者信息

机构信息

出版信息

INTRODUCTION

CASE PRESENTATION

DISCUSSION

引言

病例报告

讨论

相似文献

引用本文的文献

本文引用的文献

相似文献

引用本文的文献

本文引用的文献

使用托珠单抗治疗斑秃患者的毛发生长情况

Hair Growth in a Patient with Alopecia Areata on Tocilizumab.

作者信息

机构信息

出版信息

INTRODUCTION

CASE PRESENTATION

DISCUSSION

引言

病例报告

讨论