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一例罕见的无症状非尿路上皮膀胱肿瘤病例。

An unusual case of asymptomatic non-urothelial bladder tumour.

作者信息

Ching Daniel, Anastasiadis Eleni, Sandhu Sarb

机构信息

Fiona Stanley Hospital, Western Australia, Australia.

Department of Urology, Kingston Hospital NHS Foundation Trust, United Kingdom.

出版信息

Int J Surg Case Rep. 2016;27:18-20. doi: 10.1016/j.ijscr.2016.07.008. Epub 2016 Jul 14.

Abstract

INTRODUCTION

Non-urothelial tumours are rare and account for less than 5% of all bladder tumours. Bladder paragangliomas also known as extra-adrenal pheochromocytomas are of the non-urothelial subgroup. We present an unusual case of asymptomatic bladder paraganglioma.

CASE REPORT

A 77year old lady presented with acute abdominal pain was found to have an incidental enhancing nodule in the bladder. During cystoscopy and transurethral resection the patient experienced significant fluctuations in blood pressure that required anaesthetic adjustments. Review of histology confirmed a diagnosis of bladder paraganglioma.

DISCUSSION

Most bladder paraganglioma cases present with sympathomimetic related symptoms and microscopic haematuria but our patient was asymptomatic which resulted in inadequate pre-operative optimisation and high anaesthetic risk. Majority of paragangliomas are benign but there is a 20-40% chance of malignancy. The management options will predominantly depend on whether disease is localised, regional, metastatic or recurrent in nature.

CONCLUSION

Due to the non-specific nature of disease, variability of presentations and rare incidence, bladder paragangliomas are often not part of the urologists' differential diagnoses. In our opinion, establishing guidelines should assist to achieve a balance between anaesthetic risks, cystoscopy and follow up.

摘要

引言

非尿路上皮肿瘤较为罕见,占所有膀胱肿瘤的比例不到5%。膀胱副神经节瘤也被称为肾上腺外嗜铬细胞瘤,属于非尿路上皮亚组。我们报告一例无症状膀胱副神经节瘤的罕见病例。

病例报告

一名77岁女性因急性腹痛就诊,经检查发现膀胱内有一个偶然增强的结节。在膀胱镜检查和经尿道切除术中,患者血压出现显著波动,需要调整麻醉。组织学检查确诊为膀胱副神经节瘤。

讨论

大多数膀胱副神经节瘤病例表现为拟交感神经相关症状和镜下血尿,但我们的患者无症状,这导致术前准备不足和麻醉风险较高。大多数副神经节瘤是良性的,但有20%-40%的恶变几率。治疗方案主要取决于疾病是局限性、区域性、转移性还是复发性。

结论

由于疾病的非特异性、表现的多样性和罕见性,膀胱副神经节瘤通常不在泌尿科医生的鉴别诊断范围内。我们认为,制定指南应有助于在麻醉风险、膀胱镜检查和随访之间取得平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b8/4983148/dc165d3b3859/gr1.jpg

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