Morris Robert H
Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario, M5S3H6, Canada.
Chem Rec. 2016 Dec;16(6):2640-2654. doi: 10.1002/tcr.201600080. Epub 2016 Aug 15.
This is an overview of the hydride-containing catalysts prepared in the Morris group for the efficient hydrogenation of simple ketones, imines, nitriles and esters and the asymmetric hydrogenation and transfer hydrogenation of prochiral ketones and imines. The work was inspired by and makes use of Noyori metal-ligand bifunctional concepts involving the hydride-ruthenium amine-hydrogen HRuNH design. It describes the synthesis and some catalytic properties of hydridochloro, dihydride and amide complexes of ruthenium and in one case, osmium, with monodentate, bidentate and tetradentate phosphorus and nitrogen donor ligands. The iron hydride that has been identified in a very effective asymmetric transfer hydrogenation process is also mentioned. The link between the HMNH structure and the sense of enantioinduction is demonstrated by use of simple transition state models.
本文概述了莫里斯团队制备的含氢化物催化剂，用于简单酮、亚胺、腈和酯的高效氢化，以及前手性酮和亚胺的不对称氢化和转移氢化。这项工作受到了野依良治金属-配体双功能概念的启发，并利用了涉及氢化物-钌-胺-氢（HRuNH）设计的概念。它描述了钌以及一例锇与单齿、双齿和四齿磷和氮供体配体形成的氢氯、二氢化物和酰胺配合物的合成及一些催化性质。还提到了在一个非常有效的不对称转移氢化过程中鉴定出的氢化铁。通过使用简单的过渡态模型证明了HMNH结构与对映体诱导方向之间的联系。
