WRAP53基因rs2287499 C>G多态性与癌症风险的关联：一项荟萃分析。

Association between the WRAP53 gene rs2287499 C>G polymorphism and cancer risk: A meta-analysis.

作者信息

Cao H Y, Wang S, Zhang Z Y, Lou J Y

机构信息

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China

出版信息

Genet Mol Res. 2016 Jul 25;15(3):gmr7976. doi: 10.4238/gmr.15037976.

DOI:10.4238/gmr.15037976

PMID:27525856

Abstract

The TP53 5'-untranslated region flanking the gene WRAP53 (also known as WDR79 and TCAB1) has been hypothesized to be associated with cancer risk due to its critical function in regulating p53 levels. In this review, we analyzed the association between the WRAP53 gene rs2287499 C>G polymorphism and risk of cancer using five case-control studies, comprising seven datasets. All analyses were performed using RevMan software. In the overall analysis, no significant association between rs2287499 and risk of cancer was found. We then conducted subgroup tests, stratifying the data by cancer type, ethnicity, sample source, and quality score. Only the brain and breast cancer subgroups returned significant results, but with conflicting implications. Our concerns regarding this are discussed in detail. In conclusion, the rs2287499 polymorphism may be associated with risk of cancer. Further studies taking into consideration a broader range of cancer types and different ethnicities are warranted.

摘要

基因WRAP53（也称为WDR79和TCAB1）侧翼的TP53 5'非翻译区因其在调节p53水平方面的关键功能，被推测与癌症风险相关。在本综述中，我们使用五项病例对照研究（包含七个数据集）分析了WRAP53基因rs2287499 C>G多态性与癌症风险之间的关联。所有分析均使用RevMan软件进行。在总体分析中，未发现rs2287499与癌症风险之间存在显著关联。然后我们进行了亚组检验，按癌症类型、种族、样本来源和质量评分对数据进行分层。只有脑癌和乳腺癌亚组得出了显著结果，但含义相互矛盾。我们对此的担忧将进行详细讨论。总之，rs2287499多态性可能与癌症风险相关。有必要开展进一步研究，纳入更广泛的癌症类型和不同种族。