Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
The First Clinical Medical College of Fujian Medical University, Fuzhou, China.
PLoS One. 2018 Mar 13;13(3):e0191560. doi: 10.1371/journal.pone.0191560. eCollection 2018.
It has been reported that the functional telomerase reverse transcriptase (TERT) rs2853669 polymorphism might contribute to different types of human cancer. However, the association of this mutation with cancer remains controversial. Here, we conducted a meta-analysis to characterize this relationship.
MATERIALS AND METHODS/MAIN RESULTS: A systematic search of studies on the association of TERT rs2853669 polymorphism with all types of cancer was conducted in PubMed, Embase and Cochrane Library. The summary odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were used to pool the effect size in a fixed-effects model or a random-effects model where appropriate. A total of 13 articles and 15 case-control studies, including 9,157 cases and 11,073 controls, were included in this meta-analysis. Overall, the pooled results indicated that the rs2853669 polymorphism was significantly associated with increased cancer risk in a homozygote comparison model (CT vs. TT: OR = 1.085, 95% CI: 1.015-1.159, P = 0.016). In the stratified analyses, a significant increased cancer risk was observed in Asian, but not Caucasian patients. A subgroup analysis by cancer type also revealed a significant increase in the risk of lung cancer, but not breast cancer.
The results of this meta-analysis suggest that the TERT rs2853669 polymorphism is associated with a significantly increased risk of cancer, particularly lung cancer, in Asian populations.
已有报道称，功能性端粒酶逆转录酶（TERT）rs2853669 多态性可能与人类的多种癌症类型有关。然而，该突变与癌症的关联仍存在争议。在此，我们进行了一项荟萃分析以明确这种关系。
材料和方法/主要结果：系统检索了 PubMed、Embase 和 Cochrane Library 中关于 TERT rs2853669 多态性与所有类型癌症相关性的研究。采用固定效应模型或随机效应模型汇总合适的效应大小，汇总比值比（OR）及其相应的 95%置信区间（95%CI）。这项荟萃分析共纳入了 13 篇文章和 15 项病例对照研究，包括 9157 例病例和 11073 例对照。总体而言，汇总结果表明，rs2853669 多态性与同合子比较模型（CT 与 TT：OR=1.085，95%CI：1.015-1.159，P=0.016）中的癌症风险增加显著相关。在分层分析中，亚洲人群中观察到癌症风险显著增加，但在高加索人群中未观察到。按癌症类型进行的亚组分析也显示，肺癌风险显著增加，但乳腺癌风险未增加。
这项荟萃分析的结果表明，TERT rs2853669 多态性与亚洲人群中癌症风险显著增加相关，特别是肺癌。
