WDR79 通过抑制 SIRT4 促进胰腺导管腺癌（PDAC）的有氧糖酵解。
WDR79 promotes aerobic glycolysis of pancreatic ductal adenocarcinoma (PDAC) by the suppression of SIRT4.
作者信息
Yin Wenke, Song Xiaoyan, Xiang Yue
机构信息
Department of Pathology, Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, No. 55 Dongshun Road, Gaoping District, Nanchong, Sichuan, 637100, China.
Department of Pathology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
出版信息
Open Med (Wars). 2023 Jan 16;18(1):20220624. doi: 10.1515/med-2022-0624. eCollection 2023.
Pancreatic cancer (PC) is an aggressive malignant disease. Pancreatic ductal adenocarcinoma (PDAC) is a main type of PDAC. The inhibition of aerobic glycolysis in PC cells is one of the approaches to treat PDAC. WD repeat protein 79 (WDR79) acts as a scaffold protein and is involved in several physiological processes. Since WDR79 affects the progression of several types of cancers, whereas its role in PDAC remains unclear. This study was aimed to investigate the role of WDR79 in the progression of PDAC and clarify the mechanism. We found that WDR79 was highly expressed in PDAC cells. Knockdown of WDR79 inhibited the growth as well as the motility of PDAC cells, while overexpression of WDR79 contributed to the growth and motility. The ablation of WDR79 restrained aerobic glycolysis of PDAC cells. Mechanically, we found that WDR79 depletion increased SIRT4 expression by suppressing UHRF1 expression, which counteracted the function of WDR79 in PDAC. We thought that WDR79 could serve as a target for treating PDAC.
胰腺癌（PC）是一种侵袭性恶性疾病。胰腺导管腺癌（PDAC）是PC的主要类型。抑制PC细胞中的有氧糖酵解是治疗PDAC的方法之一。WD重复蛋白79（WDR79）作为一种支架蛋白，参与多种生理过程。由于WDR79影响多种癌症的进展，但其在PDAC中的作用尚不清楚。本研究旨在探讨WDR79在PDAC进展中的作用并阐明其机制。我们发现WDR79在PDAC细胞中高表达。敲低WDR79可抑制PDAC细胞的生长和运动，而WDR79的过表达则促进其生长和运动。WDR79的缺失抑制了PDAC细胞的有氧糖酵解。在机制上，我们发现WDR79的缺失通过抑制UHRF1的表达增加了SIRT4的表达，这抵消了WDR79在PDAC中的功能。我们认为WDR79可作为治疗PDAC的靶点。
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