Toh Hiromi, Harada Sadako, Kakudou Tomoko, Era Fumiyoshi, Tokushige Chiemi, Yoshimura Hisae, Kawashima Hironobu, Ohkubo Kumiko, Ishikura Hiroyasu, Matsunaga Akira
Rinsho Byori. 2014 Oct;62(10):931-6.
Procalcitonin (PCT) is a frequently used marker for bacterial sepsis. The present study was aimed to assess the usefulness of PCT measurement in patient with sepsis. We studied the relationship between serum PCT level and blood culture in clinical 209 cases admitted from January 2010 through June 2010. We compared PCT level with blood culture results and other clinical data, and diagnosis such as sepsis and systemic inflammatory response syndrome (SIRS) were obtained from the medical records. In the case of patients with positive blood cultures and PCT < 0.5 ng/mL, the false- positive blood culture was suspected. The possibility of bacteremia was high when PCT level was more than 0.5 ng/mL. Patients with PCT ≥ 2 ng/mL had significant correlation with the presence of sepsis. The PCT measurement could be performed and reported rapidly and provided valuable information before availability of culture results. In this study, we found that the PCT would be a useful biomarker for confirming and ruling out sepsis.
降钙素原（PCT）是细菌性脓毒症常用的标志物。本研究旨在评估PCT检测在脓毒症患者中的应用价值。我们研究了2010年1月至2010年6月收治的209例临床病例中血清PCT水平与血培养之间的关系。我们将PCT水平与血培养结果及其他临床数据进行比较，并从病历中获取脓毒症和全身炎症反应综合征（SIRS）等诊断信息。对于血培养阳性而PCT<0.5 ng/mL的患者，怀疑血培养假阳性。当PCT水平超过0.5 ng/mL时，菌血症的可能性较高。PCT≥2 ng/mL的患者与脓毒症的存在显著相关。PCT检测能够快速进行并报告结果，在培养结果出来之前提供有价值的信息。在本研究中，我们发现PCT将是用于确诊和排除脓毒症的有用生物标志物。
