Luciano Rosa, Battafarano Giulia, Saracino Rossana, Rossi Michela, Perrotta Antonio, Manco Melania, Muraca Maurizio, Del Fattore Andrea
Multi-Factorial Disease and Complex Phenotype Research Area, Bambino Gesu Children's Hospital, IRCCS, Viale di San Paolo 15, 00146, Rome, Italy.
Curr Cancer Drug Targets. 2017;17(3):203-220. doi: 10.2174/1568009616666160813190732.
Glioblastoma multiforme represents one of the most aggressive tumor of central nervous system. Current therapy includes surgery, radiation and chemotherapy. These treatments are rarely curative and glioma are associated with a poor prognosis. Nanomedicine represents the most innovative branch of medicine since many studies demonstrated great advantage in the diagnosis and therapy of several diseases. In this review we will summarize the results obtained by the use of nanoparticles and extracellular vesicles in glioblastoma. A great interest is raising from these studies that underlined the efficacy and specificity of this treatment for glioma, reducing side-effects associated with conventional therapies.
多形性胶质母细胞瘤是中枢神经系统中最具侵袭性的肿瘤之一。目前的治疗方法包括手术、放疗和化疗。这些治疗方法很少能治愈，胶质瘤的预后很差。纳米医学是医学中最具创新性的分支，因为许多研究表明其在多种疾病的诊断和治疗中具有巨大优势。在这篇综述中，我们将总结在胶质母细胞瘤中使用纳米颗粒和细胞外囊泡所取得的成果。这些研究引起了极大的兴趣，它们强调了这种治疗方法对胶质瘤的有效性和特异性，减少了与传统疗法相关的副作用。
