Gallantree-Smith Harrison C, Antonsen Simen G, Görbitz Carl H, Hansen Trond V, Nolsøe Jens M J, Stenstrøm Yngve H
Department of Chemistry, Norwegian University of Life Sciences, PO box 5003, 1432 Ås, Norway.
Org Biomol Chem. 2016 Sep 28;14(36):8433-7. doi: 10.1039/c6ob01511e. Epub 2016 Aug 16.
The first total synthesis aimed at the naturally occurring eicosanoid bicycle mucosin is reported. A practical route has been devised allowing the issues relating to the previous assignment of stereochemistry to be examined. X-ray crystallography was performed on a late stage intermediate to pinpoint the topological relationship displayed by the featured bicyclo[4.3.0]non-3-ene scaffold.
报道了首个针对天然存在的类二十烷酸双环黏液素的全合成。已设计出一条实用路线，以便对先前立体化学归属相关的问题进行研究。对一个后期中间体进行了X射线晶体学分析，以确定具有特色的双环[4.3.0]壬-3-烯支架所呈现的拓扑关系。
