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出生后发育过程中2,3-二磷酸甘油酸含量高和低的红细胞中果糖2,6-二磷酸和葡萄糖1,6-二磷酸的水平

Fructose 2,6-bisphosphate and glucose 1,6-bisphosphate levels in erythrocytes with high and low 2,3-bisphosphoglycerate content during postnatal development.

作者信息

Gallego C, Carreras J

机构信息

Departament de Ciències Fisiològiques Humanes i de la Nutrició, Facultat de Medicina, Universitat de Barcelona, Zona Universitària de Pedralbes, Spain.

出版信息

FEBS Lett. 1989 Jul 17;251(1-2):74-8. doi: 10.1016/0014-5793(89)81431-0.

DOI:10.1016/0014-5793(89)81431-0
PMID:2753166
Abstract

In rabbit and sheep erythrocytes the concentrations of 2,3-bisphosphoglycerate, fructose 2,6-bisphosphate and glucose 1,6-bisphosphate suffer important changes after birth, which differ in both species. The changes of fructose 2,6-bisphosphate and glucose 1,6-bisphosphate correlate with the changes in the levels of the enzymatic activities involved in their synthesis. The change of 2,3-bisphosphoglycerate levels in rabbit but not in sheep erythrocytes could be explained by the changes of the phosphofructokinase/pyruvate kinase and 2,3-bisphosphoglycerate synthase/2,3-bisphosphoglycerate phosphatase activity ratios.

摘要

在兔和羊的红细胞中,出生后2,3-二磷酸甘油酸、果糖2,6-二磷酸和葡萄糖1,6-二磷酸的浓度会发生显著变化,且这两种物种的变化情况有所不同。果糖2,6-二磷酸和葡萄糖1,6-二磷酸的变化与参与其合成的酶活性水平的变化相关。兔红细胞中2,3-二磷酸甘油酸水平的变化,而羊红细胞中则不然,这可以通过磷酸果糖激酶/丙酮酸激酶和2,3-二磷酸甘油酸合酶/2,3-二磷酸甘油酸磷酸酶活性比值的变化来解释。

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引用本文的文献

1
2,3-Bisphosphoglycerate, fructose, 2,6-bisphosphate and glucose 1,6-bisphosphate during maturation of reticulocytes with low 2,3-bisphosphoglycerate content.在2,3-二磷酸甘油酸含量较低的网织红细胞成熟过程中的2,3-二磷酸甘油酸、果糖、2,6-二磷酸果糖和1,6-二磷酸葡萄糖。
Mol Cell Biochem. 1990 Dec 3;99(1):21-4. doi: 10.1007/BF01261389.