Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA.
Immunity. 2016 Aug 16;45(2):227-8. doi: 10.1016/j.immuni.2016.08.006.
The innate response to many pathogens involves type I interferon production that is initiated upon cytosolic detection of double-stranded DNA (dsDNA), but how dsDNA is detected is controversial. In this issue of Immunity, Gray et al. (2016) use genetics to bring some much-needed clarity to the field.
机体对许多病原体的先天反应涉及到 I 型干扰素的产生，这种产生是在细胞质中检测到双链 DNA（dsDNA）后启动的，但是 dsDNA 是如何被检测到的还存在争议。在本期《免疫》杂志中，Gray 等人（2016）利用遗传学为该领域带来了一些急需的澄清。
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