O'Neill Luke A J
School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland.
Cell. 2009 Aug 7;138(3):428-30. doi: 10.1016/j.cell.2009.07.021.
Microbial DNA in the cytosol induces production of interferon-beta (IFN-beta) and an innate immune response. Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA release by pathogenic bacteria and viruses in the host cell cytosol to IFN-beta production and innate immunity.
胞质溶胶中的微生物DNA可诱导β干扰素（IFN-β）的产生及先天性免疫反应。邱等人（2009年）现在认为，胞质DNA依赖性RNA聚合酶III作为DNA传感器，将宿主细胞胞质溶胶中致病细菌和病毒释放的DNA与IFN-β的产生及先天性免疫联系起来。
