来自埃及矢车菊的新型细胞毒性愈创木烷型倍半萜内酯

New Cytotoxic Guaianolides from Centaurea aegyptiaca.

作者信息

Sary Hanan G, Singab Abdel Nasser B, Orabi Khaled Y

出版信息

Nat Prod Commun. 2016 Jun;11(6):711-4.

Abstract

The ethanol extract of Centaurea aegyptiaca aerial parts afforded two new chlorinated bioactive guaianolides, cenegyptin A (1) and cenegyptin B (2), in addition to four known sesquiterpenes (3 - 6). Their identities were established on the basis of their spectral data. The cytotoxicity (IC50, μM) of compounds 1 - 6 were evaluated against hepatic (HEPG2) and laryngeal (HEP2) carcinoma cell lines in comparison with normal fibroblasts (BHK). Compound 1 showed cytotoxic activity against HEPG2 and HEP2 with IC50 values of 7.2 ± 0.04 and 7.5 ± 0.02, respectively. However, compound 2 exhibited only a limited toxicity against both cell lines.

摘要

埃及矢车菊地上部分的乙醇提取物除了得到四种已知的倍半萜（3 - 6）外，还提供了两种新的氯化生物活性愈创木烷型内酯，即埃及矢车菊素A（1）和埃及矢车菊素B（2）。它们的结构通过光谱数据得以确定。与正常成纤维细胞（BHK）相比，评估了化合物1 - 6对肝癌（HEPG2）和喉癌（HEP2）细胞系的细胞毒性（IC50，μM）。化合物1对HEPG2和HEP2表现出细胞毒性活性，IC50值分别为7.2±0.04和7.5±0.02。然而，化合物2对这两种细胞系仅表现出有限的毒性。