利用长春花叶片提取物生物合成银纳米颗粒并评估其抗氧化、抗菌和伤口愈合活性。
Biosynthesis of silver nanoparticles from Catharanthus roseus leaf extract and assessing their antioxidant, antimicrobial, and wound-healing activities.
作者信息
Al-Shmgani Hanady S A, Mohammed Wasnaa H, Sulaiman Ghassan M, Saadoon Ali H
机构信息
a Biology Department, College of Education for Pure Science/Ibn al-Haitham , University of Baghdad , Baghdad , Iraq.
b Biotechnology Division, Applied Science Department , University of Technology , Baghdad , Iraq.
出版信息
Artif Cells Nanomed Biotechnol. 2017 Sep;45(6):1-7. doi: 10.1080/21691401.2016.1220950. Epub 2016 Aug 18.
Biosynthesis of silver nanoparticles (AgNPs) from Catharanthus roseus leaf extract was carried out, and their characterization, as well as antioxidant, antimicrobial, and wound-healing activities were evaluated. Color change, UV-vis spectrum, XRD, FTIR, and AFM assessments supported the biosynthesis and characterization of AgNPs. The synthesized AgNPs showed strong in vitro antioxidant and antimicrobial activities against various pathogens. The in vivo assessment of wound healing in AgNPs-treated mice revealed their effectiveness in closuring and reducing size of wounds. Such potent bioactivity may justify their biomedical use as antioxidant and antimicrobial agents for controlling various health-related diseases, particularly in wound healing.
利用长春花叶片提取物进行了银纳米颗粒（AgNPs）的生物合成，并对其进行了表征，同时评估了其抗氧化、抗菌和伤口愈合活性。颜色变化、紫外可见光谱、X射线衍射、傅里叶变换红外光谱和原子力显微镜评估支持了AgNPs的生物合成和表征。合成的AgNPs对多种病原体表现出强大的体外抗氧化和抗菌活性。对经AgNPs处理的小鼠进行的伤口愈合体内评估显示，它们在闭合伤口和减小伤口尺寸方面有效。这种强大的生物活性可能证明它们作为抗氧化剂和抗菌剂在控制各种与健康相关疾病，特别是伤口愈合方面的生物医学用途是合理的。
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